Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures

Shota Kurotsu, Taketaro Sadahiro, Ryo Fujita, Hidenori Tani, Hiroyuki Yamakawa, Fumiya Tamura, Mari Isomi, Hidenori Kojima, Yu Yamada, Yuto Abe, Yoshiko Murakata, Tatsuya Akiyama, Naoto Muraoka, Ichiro Harada, Takeshi Suzuki, Keiichi Fukuda, Masaki Ieda

Research output: Contribution to journalArticlepeer-review

Abstract

In this article, Ieda and colleagues showed that a soft matrix, which is comparable with native myocardium, efficiently promoted cardiac reprogramming. This soft matrix enhanced cardiac reprogramming via inhibition of integrin, Rho/ROCK, actomyosin, and YAP/TAZ signaling and subsequent suppression of fibroblast programs, which were activated on conventional rigid substrates, thus demonstrating that mechanotransduction plays a critical role in cardiac reprogramming.

Original languageEnglish
Pages (from-to)612-628
Number of pages17
JournalStem cell reports
Volume15
Issue number3
DOIs
Publication statusPublished - 2020 Sep 8

Keywords

  • YAP/TAZ
  • cardiac reprogramming
  • mechanotransduction
  • myocardium
  • soft matrix

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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