Solid-phase modular synthesis of park nucleotide and lipids i and II analogues

Akira Katsuyama, Kousuke Sato, Fumika Yakushiji, Takanori Matsumaru, Satoshi Ichikawa

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

A solid-phase synthesis of Park nucleotide as well as lipids I and II analogues, which is applicable to the synthesis of a range of analogues, is described in this work. This technique allows highly functionalized macromolecules to be modularly labeled. Multiple steps are used in a short time (4 d) with a single purification step to synthesize the molecules by solid-phase synthesis.

Original languageEnglish
Pages (from-to)84-95
Number of pages12
JournalChemical and Pharmaceutical Bulletin
Volume66
Issue number1
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Fingerprint

Solid-Phase Synthesis Techniques
Nucleotides
Lipids
Macromolecules
Purification
Molecules
muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol
lipid I

Keywords

  • Natural product
  • Peptidoglycan
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

Cite this

Solid-phase modular synthesis of park nucleotide and lipids i and II analogues. / Katsuyama, Akira; Sato, Kousuke; Yakushiji, Fumika; Matsumaru, Takanori; Ichikawa, Satoshi.

In: Chemical and Pharmaceutical Bulletin, Vol. 66, No. 1, 01.01.2018, p. 84-95.

Research output: Contribution to journalReview article

Katsuyama, A, Sato, K, Yakushiji, F, Matsumaru, T & Ichikawa, S 2018, 'Solid-phase modular synthesis of park nucleotide and lipids i and II analogues', Chemical and Pharmaceutical Bulletin, vol. 66, no. 1, pp. 84-95.
Katsuyama, Akira ; Sato, Kousuke ; Yakushiji, Fumika ; Matsumaru, Takanori ; Ichikawa, Satoshi. / Solid-phase modular synthesis of park nucleotide and lipids i and II analogues. In: Chemical and Pharmaceutical Bulletin. 2018 ; Vol. 66, No. 1. pp. 84-95.
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