Solid-phase modular synthesis of park nucleotide and lipids i and II analogues

Akira Katsuyama, Kousuke Sato, Fumika Yakushiji, Takanori Matsumaru, Satoshi Ichikawa

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

A solid-phase synthesis of Park nucleotide as well as lipids I and II analogues, which is applicable to the synthesis of a range of analogues, is described in this work. This technique allows highly functionalized macromolecules to be modularly labeled. Multiple steps are used in a short time (4 d) with a single purification step to synthesize the molecules by solid-phase synthesis.

Original languageEnglish
Pages (from-to)84-95
Number of pages12
JournalChemical and Pharmaceutical Bulletin
Volume66
Issue number1
Publication statusPublished - 2018 Jan 1
Externally publishedYes

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Keywords

  • Natural product
  • Peptidoglycan
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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