Solid state radical recombination and charge transfer across the boundary between indomethacin and silica under mechanical stress

Tomoyuki Watanabe, Susumu Hasegawa, Naoki Wakiyama, Fusao Usui, Akira Kusai, Tetsuhiko Isobe, Mamoru Senna

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A composite of indomethacin (IM) and SiO2 was prepared in a solid state by cogrinding. Dehydration was observed as a consequence of a chemical reaction between silanol groups of SiO2 and carboxyl groups of IM. Several specific radical species found on separately ground SiO2 disappeared preferentially after cogrinding as a result of their recombination. These chemical interactions under mechanical stress bring about a charge transfer, as confirmed by X-ray photoelectron spectroscopy, leading to Si-O-C bridging bond formation at the IM/SiO2 interface.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalJournal of Solid State Chemistry
Volume164
Issue number1
DOIs
Publication statusPublished - 2002

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Dehydration
Indomethacin
Silicon Dioxide
Charge transfer
Chemical reactions
X ray photoelectron spectroscopy
Silica
charge transfer
silicon dioxide
solid state
Composite materials
carboxyl group
dehydration
chemical reactions
photoelectron spectroscopy
composite materials
x rays
interactions

Keywords

  • Charge transfer
  • Electronegativity equalization
  • Mechanochemical
  • Mechanoradical
  • Silica composite

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Solid state radical recombination and charge transfer across the boundary between indomethacin and silica under mechanical stress. / Watanabe, Tomoyuki; Hasegawa, Susumu; Wakiyama, Naoki; Usui, Fusao; Kusai, Akira; Isobe, Tetsuhiko; Senna, Mamoru.

In: Journal of Solid State Chemistry, Vol. 164, No. 1, 2002, p. 27-33.

Research output: Contribution to journalArticle

Watanabe, Tomoyuki ; Hasegawa, Susumu ; Wakiyama, Naoki ; Usui, Fusao ; Kusai, Akira ; Isobe, Tetsuhiko ; Senna, Mamoru. / Solid state radical recombination and charge transfer across the boundary between indomethacin and silica under mechanical stress. In: Journal of Solid State Chemistry. 2002 ; Vol. 164, No. 1. pp. 27-33.
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AU - Isobe, Tetsuhiko

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