Solid state radical recombination and charge transfer across the boundary between indomethacin and silica under mechanical stress

Tomoyuki Watanabe; Susumu Hasegawa; Naoki Wakiyama; Fusao Usui; Akira Kusai; Tetsuhiko Isobe; Mamoru Senna

doi:10.1006/jssc.2001.9436

Solid state radical recombination and charge transfer across the boundary between indomethacin and silica under mechanical stress

Tomoyuki Watanabe, Susumu Hasegawa, Naoki Wakiyama, Fusao Usui, Akira Kusai, Tetsuhiko Isobe, Mamoru Senna

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

A composite of indomethacin (IM) and SiO₂ was prepared in a solid state by cogrinding. Dehydration was observed as a consequence of a chemical reaction between silanol groups of SiO₂ and carboxyl groups of IM. Several specific radical species found on separately ground SiO₂ disappeared preferentially after cogrinding as a result of their recombination. These chemical interactions under mechanical stress bring about a charge transfer, as confirmed by X-ray photoelectron spectroscopy, leading to Si-O-C bridging bond formation at the IM/SiO₂ interface.

Original language	English
Pages (from-to)	27-33
Number of pages	7
Journal	Journal of Solid State Chemistry
Volume	164
Issue number	1
DOIs	https://doi.org/10.1006/jssc.2001.9436
Publication status	Published - 2002

Keywords

Charge transfer
Electronegativity equalization
Mechanochemical
Mechanoradical
Silica composite

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Condensed Matter Physics
Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1006/jssc.2001.9436

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abstract = "A composite of indomethacin (IM) and SiO2 was prepared in a solid state by cogrinding. Dehydration was observed as a consequence of a chemical reaction between silanol groups of SiO2 and carboxyl groups of IM. Several specific radical species found on separately ground SiO2 disappeared preferentially after cogrinding as a result of their recombination. These chemical interactions under mechanical stress bring about a charge transfer, as confirmed by X-ray photoelectron spectroscopy, leading to Si-O-C bridging bond formation at the IM/SiO2 interface.",

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T1 - Solid state radical recombination and charge transfer across the boundary between indomethacin and silica under mechanical stress

AU - Watanabe, Tomoyuki

AU - Hasegawa, Susumu

AU - Wakiyama, Naoki

AU - Usui, Fusao

AU - Kusai, Akira

AU - Isobe, Tetsuhiko

AU - Senna, Mamoru

PY - 2002

Y1 - 2002

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AB - A composite of indomethacin (IM) and SiO2 was prepared in a solid state by cogrinding. Dehydration was observed as a consequence of a chemical reaction between silanol groups of SiO2 and carboxyl groups of IM. Several specific radical species found on separately ground SiO2 disappeared preferentially after cogrinding as a result of their recombination. These chemical interactions under mechanical stress bring about a charge transfer, as confirmed by X-ray photoelectron spectroscopy, leading to Si-O-C bridging bond formation at the IM/SiO2 interface.

KW - Charge transfer

KW - Electronegativity equalization

KW - Mechanochemical

KW - Mechanoradical

KW - Silica composite

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Solid state radical recombination and charge transfer across the boundary between indomethacin and silica under mechanical stress

Abstract

Keywords

ASJC Scopus subject areas

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