Solid-state 17O NMR analysis of synthetically 17O-enriched D-glucosamine

Kazuhiko Yamada, Yoshiki Yamaguchi, Yoshinori Uekusa, Kazumasa Aoki, Ichio Shimada, Takumi Yamaguchi, Koichi Kato

Research output: Contribution to journalArticlepeer-review

Abstract

The hydroxyl groups of carbohydrates are critical determinants of their conformational dynamics and intermolecular interactions but are difficult to characterize by conventional 1H nuclear magnetic resonance (NMR) approaches in solution. Here, we report a solid-state 17O NMR analysis of synthetic glucosamine with 17O enrichment at position 6. Based on magic-angle spinning and stationary spectral data obtained at varying magnetic fields in conjunction with quantum chemical calculations, we successfully estimated 17O chemical shift and electric field gradient tensors, providing benchmark for 17O NMR analyses of oligosaccharide structures.

Original languageEnglish
Article number137455
JournalChemical Physics Letters
Volume749
DOIs
Publication statusPublished - 2020 Jun 16

Keywords

  • Chemical shift
  • D-Glucosamine
  • Electric field gradient
  • Hydroxyl group
  • Quantum chemical calculation
  • Solid-state O NMR spectroscopy
  • Stable isotope enrichment

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'Solid-state <sup>17</sup>O NMR analysis of synthetically <sup>17</sup>O-enriched D-glucosamine'. Together they form a unique fingerprint.

Cite this