Solitary pure ground-glass nodules 5 mm or smaller

Frequency of growth

Ryutaro Kakinuma, Yukio Muramatsu, Masahiko Kusumoto, Takaaki Tsuchida, Koji Tsuta, Akiko Miyagi Maeshima, Hisao Asamura, Noriyuki Moriyama

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Purpose: To clarify the percentage of solitary pure ground-glass nodules (SPGGNs) 5 mm or smaller that grow and develop into invasive adenocarcinomas. Materials and Methods: This study was approved by the institutional review board, and informed consent was obtained from all people who were screened. From February 2004 through December 2007, 7294 participants underwent screening for lung cancer with computed tomographic (CT) imaging. The nodule database was reviewed to identify SPGGNs 5 mm or smaller. Growth of the SPGGNs was evaluated as of March 31, 2013. In cases of pathologic analysis-proven adenocarcinomas that developed from SPGGNs 5 mm or smaller, solid components were evaluated. Percentages, 95% confidence intervals, and means were calculated. Results: At baseline screening, 438 SPGGNs 5 mm or smaller were identified, and during the study period one SPGGN 5 mm or smaller developed de novo. Of the 439 SPGGNs, 394 were stable and 45 (10.3% [95% confidence interval: 7.5%, 13.7%]), including newly developed SPGGN, grew. Of the 45 SPGGNs that grew, 0.9% (four of 439 [95% confidence interval: 0.3%, 2.3%]) developed into adenocarcinomas (two minimally invasive [including the newly developed SPGGN] and two invasive). The mean period between baseline CT screening and the appearance of solid components in the four adenocarcinomas was 3.6 years. Conclusion: Of SPGGNs 5 mm or smaller, approximately 10% will grow and 1% will develop into invasive adenocarcinomas or minimally invasive adenocarcinomas. SPGGNs 5 mm or smaller should be rescanned 3.5 years later to look for development of a solid component.

Original languageEnglish
Pages (from-to)873-882
Number of pages10
JournalRadiology
Volume276
Issue number3
DOIs
Publication statusPublished - 2015 Sep 1

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Glass
Growth
Adenocarcinoma
Confidence Intervals
Research Ethics Committees
Informed Consent
Lung Neoplasms
Databases

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Kakinuma, R., Muramatsu, Y., Kusumoto, M., Tsuchida, T., Tsuta, K., Maeshima, A. M., ... Moriyama, N. (2015). Solitary pure ground-glass nodules 5 mm or smaller: Frequency of growth. Radiology, 276(3), 873-882. https://doi.org/10.1148/radiol.2015141071

Solitary pure ground-glass nodules 5 mm or smaller : Frequency of growth. / Kakinuma, Ryutaro; Muramatsu, Yukio; Kusumoto, Masahiko; Tsuchida, Takaaki; Tsuta, Koji; Maeshima, Akiko Miyagi; Asamura, Hisao; Moriyama, Noriyuki.

In: Radiology, Vol. 276, No. 3, 01.09.2015, p. 873-882.

Research output: Contribution to journalArticle

Kakinuma, R, Muramatsu, Y, Kusumoto, M, Tsuchida, T, Tsuta, K, Maeshima, AM, Asamura, H & Moriyama, N 2015, 'Solitary pure ground-glass nodules 5 mm or smaller: Frequency of growth', Radiology, vol. 276, no. 3, pp. 873-882. https://doi.org/10.1148/radiol.2015141071
Kakinuma R, Muramatsu Y, Kusumoto M, Tsuchida T, Tsuta K, Maeshima AM et al. Solitary pure ground-glass nodules 5 mm or smaller: Frequency of growth. Radiology. 2015 Sep 1;276(3):873-882. https://doi.org/10.1148/radiol.2015141071
Kakinuma, Ryutaro ; Muramatsu, Yukio ; Kusumoto, Masahiko ; Tsuchida, Takaaki ; Tsuta, Koji ; Maeshima, Akiko Miyagi ; Asamura, Hisao ; Moriyama, Noriyuki. / Solitary pure ground-glass nodules 5 mm or smaller : Frequency of growth. In: Radiology. 2015 ; Vol. 276, No. 3. pp. 873-882.
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abstract = "Purpose: To clarify the percentage of solitary pure ground-glass nodules (SPGGNs) 5 mm or smaller that grow and develop into invasive adenocarcinomas. Materials and Methods: This study was approved by the institutional review board, and informed consent was obtained from all people who were screened. From February 2004 through December 2007, 7294 participants underwent screening for lung cancer with computed tomographic (CT) imaging. The nodule database was reviewed to identify SPGGNs 5 mm or smaller. Growth of the SPGGNs was evaluated as of March 31, 2013. In cases of pathologic analysis-proven adenocarcinomas that developed from SPGGNs 5 mm or smaller, solid components were evaluated. Percentages, 95{\%} confidence intervals, and means were calculated. Results: At baseline screening, 438 SPGGNs 5 mm or smaller were identified, and during the study period one SPGGN 5 mm or smaller developed de novo. Of the 439 SPGGNs, 394 were stable and 45 (10.3{\%} [95{\%} confidence interval: 7.5{\%}, 13.7{\%}]), including newly developed SPGGN, grew. Of the 45 SPGGNs that grew, 0.9{\%} (four of 439 [95{\%} confidence interval: 0.3{\%}, 2.3{\%}]) developed into adenocarcinomas (two minimally invasive [including the newly developed SPGGN] and two invasive). The mean period between baseline CT screening and the appearance of solid components in the four adenocarcinomas was 3.6 years. Conclusion: Of SPGGNs 5 mm or smaller, approximately 10{\%} will grow and 1{\%} will develop into invasive adenocarcinomas or minimally invasive adenocarcinomas. SPGGNs 5 mm or smaller should be rescanned 3.5 years later to look for development of a solid component.",
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AU - Kakinuma, Ryutaro

AU - Muramatsu, Yukio

AU - Kusumoto, Masahiko

AU - Tsuchida, Takaaki

AU - Tsuta, Koji

AU - Maeshima, Akiko Miyagi

AU - Asamura, Hisao

AU - Moriyama, Noriyuki

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N2 - Purpose: To clarify the percentage of solitary pure ground-glass nodules (SPGGNs) 5 mm or smaller that grow and develop into invasive adenocarcinomas. Materials and Methods: This study was approved by the institutional review board, and informed consent was obtained from all people who were screened. From February 2004 through December 2007, 7294 participants underwent screening for lung cancer with computed tomographic (CT) imaging. The nodule database was reviewed to identify SPGGNs 5 mm or smaller. Growth of the SPGGNs was evaluated as of March 31, 2013. In cases of pathologic analysis-proven adenocarcinomas that developed from SPGGNs 5 mm or smaller, solid components were evaluated. Percentages, 95% confidence intervals, and means were calculated. Results: At baseline screening, 438 SPGGNs 5 mm or smaller were identified, and during the study period one SPGGN 5 mm or smaller developed de novo. Of the 439 SPGGNs, 394 were stable and 45 (10.3% [95% confidence interval: 7.5%, 13.7%]), including newly developed SPGGN, grew. Of the 45 SPGGNs that grew, 0.9% (four of 439 [95% confidence interval: 0.3%, 2.3%]) developed into adenocarcinomas (two minimally invasive [including the newly developed SPGGN] and two invasive). The mean period between baseline CT screening and the appearance of solid components in the four adenocarcinomas was 3.6 years. Conclusion: Of SPGGNs 5 mm or smaller, approximately 10% will grow and 1% will develop into invasive adenocarcinomas or minimally invasive adenocarcinomas. SPGGNs 5 mm or smaller should be rescanned 3.5 years later to look for development of a solid component.

AB - Purpose: To clarify the percentage of solitary pure ground-glass nodules (SPGGNs) 5 mm or smaller that grow and develop into invasive adenocarcinomas. Materials and Methods: This study was approved by the institutional review board, and informed consent was obtained from all people who were screened. From February 2004 through December 2007, 7294 participants underwent screening for lung cancer with computed tomographic (CT) imaging. The nodule database was reviewed to identify SPGGNs 5 mm or smaller. Growth of the SPGGNs was evaluated as of March 31, 2013. In cases of pathologic analysis-proven adenocarcinomas that developed from SPGGNs 5 mm or smaller, solid components were evaluated. Percentages, 95% confidence intervals, and means were calculated. Results: At baseline screening, 438 SPGGNs 5 mm or smaller were identified, and during the study period one SPGGN 5 mm or smaller developed de novo. Of the 439 SPGGNs, 394 were stable and 45 (10.3% [95% confidence interval: 7.5%, 13.7%]), including newly developed SPGGN, grew. Of the 45 SPGGNs that grew, 0.9% (four of 439 [95% confidence interval: 0.3%, 2.3%]) developed into adenocarcinomas (two minimally invasive [including the newly developed SPGGN] and two invasive). The mean period between baseline CT screening and the appearance of solid components in the four adenocarcinomas was 3.6 years. Conclusion: Of SPGGNs 5 mm or smaller, approximately 10% will grow and 1% will develop into invasive adenocarcinomas or minimally invasive adenocarcinomas. SPGGNs 5 mm or smaller should be rescanned 3.5 years later to look for development of a solid component.

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