Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

Masahiro Ogata, K. Oka, Masako Seki, Midori Hoshi, Hirokatsu Takatsu, Tadahiko Mashino, Shiro Urano, Toyoshige Endo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.

Original languageEnglish
Pages (from-to)1565-1568
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number8
DOIs
Publication statusPublished - 2007 Aug

Fingerprint

Solubility
Ascorbic Acid
Anti-Bacterial Agents
Water
Monosaccharides
Gram-Positive Bacteria
dipropofol

Keywords

  • Ascorbic acid
  • Dipropofol
  • Monosaccharide
  • Solubilization

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid. / Ogata, Masahiro; Oka, K.; Seki, Masako; Hoshi, Midori; Takatsu, Hirokatsu; Mashino, Tadahiko; Urano, Shiro; Endo, Toyoshige.

In: Biological and Pharmaceutical Bulletin, Vol. 30, No. 8, 08.2007, p. 1565-1568.

Research output: Contribution to journalArticle

Ogata, Masahiro ; Oka, K. ; Seki, Masako ; Hoshi, Midori ; Takatsu, Hirokatsu ; Mashino, Tadahiko ; Urano, Shiro ; Endo, Toyoshige. / Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid. In: Biological and Pharmaceutical Bulletin. 2007 ; Vol. 30, No. 8. pp. 1565-1568.
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