Soluble form of P-selectin in plasma is elevated in acute lung injury

F. Sakamaki, A. Ishizaka, M. Handa, Seitaro Fujishima, T. Urano, K. Sayama, H. Nakamura, M. Kanazawa, T. Kawashiro, M. Katayama, Y. Ikeda

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Abstract

A number of adhesion molecules on neutrophils and the pulmonary capillary endothelium mediate the neutrophil accumulation in the lungs at the onset of adult respiratory distress syndrome or acute lung injury (ALI). P-selectin, located on both vascular endothelial cells and platelets, has been shown to be one of these neutrophil-endothelial cell adhesion molecules. In this study, we measured the soluble form of P-selectin in plasma (PPS) from 19 patients (surviving, 11; deceased, 8) with ALI due to various causes and assessed the clinical significance of this measurement. Twelve healthy subjects and 29 patients with other pulmonary diseases, including idiopathic pulmonary fibrosis (IPF) (n = 8), sarcoidosis (n = 5), pneumonia (n = 8), and sepsis without ALI (n = 8) were also studied for comparison. PPS in patients with ALI (474.5 ± 366.8 ng/ml, mean ± SD) were significantly higher than those in control subjects (98.8 ± 39.7, p < 0.01) and in patients with IPF (210.4 ± 76.6, p < 0.05), sarcoidosis (135.2 ± 71.5, p < 0.05), pneumonia (225.3 ± 81.0, p < 0.05), and sepals without ALI (271.8 ± 46.5, p < 0.05). There was no significant difference in PPS levels between seven patients with and 12 patients without multiple organ failure. Lung injury scores correlated significantly with the PPS level (r = 0.605, p < 0.05). PPS levels of deceased patients with ALI (841.0 ± 252.4) were significantly higher than those of surviving patients with ALI (208.0 ± 109.2, p < 0.01). These findings suggest that PPS levels were elevated in the plasma of patients with ALI, especially in those who subsequently died, as compared with those in patients with other pulmonary disease or sepsis without ALI.

Original languageEnglish
Pages (from-to)1821-1826
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume151
Issue number6
Publication statusPublished - 1995

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P-Selectin
Acute Lung Injury
Idiopathic Pulmonary Fibrosis
Neutrophils
Sarcoidosis
Lung Diseases
Sepsis
Pneumonia
Endothelial Cells
Lung
Multiple Organ Failure
Adult Respiratory Distress Syndrome
Vascular Endothelium
Cell Adhesion Molecules
Lung Injury
Healthy Volunteers
Blood Platelets

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Sakamaki, F., Ishizaka, A., Handa, M., Fujishima, S., Urano, T., Sayama, K., ... Ikeda, Y. (1995). Soluble form of P-selectin in plasma is elevated in acute lung injury. American Journal of Respiratory and Critical Care Medicine, 151(6), 1821-1826.

Soluble form of P-selectin in plasma is elevated in acute lung injury. / Sakamaki, F.; Ishizaka, A.; Handa, M.; Fujishima, Seitaro; Urano, T.; Sayama, K.; Nakamura, H.; Kanazawa, M.; Kawashiro, T.; Katayama, M.; Ikeda, Y.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 151, No. 6, 1995, p. 1821-1826.

Research output: Contribution to journalArticle

Sakamaki, F, Ishizaka, A, Handa, M, Fujishima, S, Urano, T, Sayama, K, Nakamura, H, Kanazawa, M, Kawashiro, T, Katayama, M & Ikeda, Y 1995, 'Soluble form of P-selectin in plasma is elevated in acute lung injury', American Journal of Respiratory and Critical Care Medicine, vol. 151, no. 6, pp. 1821-1826.
Sakamaki, F. ; Ishizaka, A. ; Handa, M. ; Fujishima, Seitaro ; Urano, T. ; Sayama, K. ; Nakamura, H. ; Kanazawa, M. ; Kawashiro, T. ; Katayama, M. ; Ikeda, Y. / Soluble form of P-selectin in plasma is elevated in acute lung injury. In: American Journal of Respiratory and Critical Care Medicine. 1995 ; Vol. 151, No. 6. pp. 1821-1826.
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abstract = "A number of adhesion molecules on neutrophils and the pulmonary capillary endothelium mediate the neutrophil accumulation in the lungs at the onset of adult respiratory distress syndrome or acute lung injury (ALI). P-selectin, located on both vascular endothelial cells and platelets, has been shown to be one of these neutrophil-endothelial cell adhesion molecules. In this study, we measured the soluble form of P-selectin in plasma (PPS) from 19 patients (surviving, 11; deceased, 8) with ALI due to various causes and assessed the clinical significance of this measurement. Twelve healthy subjects and 29 patients with other pulmonary diseases, including idiopathic pulmonary fibrosis (IPF) (n = 8), sarcoidosis (n = 5), pneumonia (n = 8), and sepsis without ALI (n = 8) were also studied for comparison. PPS in patients with ALI (474.5 ± 366.8 ng/ml, mean ± SD) were significantly higher than those in control subjects (98.8 ± 39.7, p < 0.01) and in patients with IPF (210.4 ± 76.6, p < 0.05), sarcoidosis (135.2 ± 71.5, p < 0.05), pneumonia (225.3 ± 81.0, p < 0.05), and sepals without ALI (271.8 ± 46.5, p < 0.05). There was no significant difference in PPS levels between seven patients with and 12 patients without multiple organ failure. Lung injury scores correlated significantly with the PPS level (r = 0.605, p < 0.05). PPS levels of deceased patients with ALI (841.0 ± 252.4) were significantly higher than those of surviving patients with ALI (208.0 ± 109.2, p < 0.01). These findings suggest that PPS levels were elevated in the plasma of patients with ALI, especially in those who subsequently died, as compared with those in patients with other pulmonary disease or sepsis without ALI.",
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AU - Sakamaki, F.

AU - Ishizaka, A.

AU - Handa, M.

AU - Fujishima, Seitaro

AU - Urano, T.

AU - Sayama, K.

AU - Nakamura, H.

AU - Kanazawa, M.

AU - Kawashiro, T.

AU - Katayama, M.

AU - Ikeda, Y.

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N2 - A number of adhesion molecules on neutrophils and the pulmonary capillary endothelium mediate the neutrophil accumulation in the lungs at the onset of adult respiratory distress syndrome or acute lung injury (ALI). P-selectin, located on both vascular endothelial cells and platelets, has been shown to be one of these neutrophil-endothelial cell adhesion molecules. In this study, we measured the soluble form of P-selectin in plasma (PPS) from 19 patients (surviving, 11; deceased, 8) with ALI due to various causes and assessed the clinical significance of this measurement. Twelve healthy subjects and 29 patients with other pulmonary diseases, including idiopathic pulmonary fibrosis (IPF) (n = 8), sarcoidosis (n = 5), pneumonia (n = 8), and sepsis without ALI (n = 8) were also studied for comparison. PPS in patients with ALI (474.5 ± 366.8 ng/ml, mean ± SD) were significantly higher than those in control subjects (98.8 ± 39.7, p < 0.01) and in patients with IPF (210.4 ± 76.6, p < 0.05), sarcoidosis (135.2 ± 71.5, p < 0.05), pneumonia (225.3 ± 81.0, p < 0.05), and sepals without ALI (271.8 ± 46.5, p < 0.05). There was no significant difference in PPS levels between seven patients with and 12 patients without multiple organ failure. Lung injury scores correlated significantly with the PPS level (r = 0.605, p < 0.05). PPS levels of deceased patients with ALI (841.0 ± 252.4) were significantly higher than those of surviving patients with ALI (208.0 ± 109.2, p < 0.01). These findings suggest that PPS levels were elevated in the plasma of patients with ALI, especially in those who subsequently died, as compared with those in patients with other pulmonary disease or sepsis without ALI.

AB - A number of adhesion molecules on neutrophils and the pulmonary capillary endothelium mediate the neutrophil accumulation in the lungs at the onset of adult respiratory distress syndrome or acute lung injury (ALI). P-selectin, located on both vascular endothelial cells and platelets, has been shown to be one of these neutrophil-endothelial cell adhesion molecules. In this study, we measured the soluble form of P-selectin in plasma (PPS) from 19 patients (surviving, 11; deceased, 8) with ALI due to various causes and assessed the clinical significance of this measurement. Twelve healthy subjects and 29 patients with other pulmonary diseases, including idiopathic pulmonary fibrosis (IPF) (n = 8), sarcoidosis (n = 5), pneumonia (n = 8), and sepsis without ALI (n = 8) were also studied for comparison. PPS in patients with ALI (474.5 ± 366.8 ng/ml, mean ± SD) were significantly higher than those in control subjects (98.8 ± 39.7, p < 0.01) and in patients with IPF (210.4 ± 76.6, p < 0.05), sarcoidosis (135.2 ± 71.5, p < 0.05), pneumonia (225.3 ± 81.0, p < 0.05), and sepals without ALI (271.8 ± 46.5, p < 0.05). There was no significant difference in PPS levels between seven patients with and 12 patients without multiple organ failure. Lung injury scores correlated significantly with the PPS level (r = 0.605, p < 0.05). PPS levels of deceased patients with ALI (841.0 ± 252.4) were significantly higher than those of surviving patients with ALI (208.0 ± 109.2, p < 0.01). These findings suggest that PPS levels were elevated in the plasma of patients with ALI, especially in those who subsequently died, as compared with those in patients with other pulmonary disease or sepsis without ALI.

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