Solute diffusion through the fibrotic tissue formed around a protective cage system for implantable sensors

Hikaru Ito, Gunawan Setia Prihandana, Kohei Tanimura, Yuki Hori, Orhan Soykan, Ryo Sudo, Norihisa Miki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biocompatible packaging is crucial in developing implantable sensors. It should allow solutes of interest to diffuse through while minimizing inflammatory response to the packaging and the sensors. In this study, a cage system made of a metal mesh cylinder surrounded by a polyvinyl alcohol (PVA) sponge material was implanted into rats, and fibrotic tissue was formed around the cage system. We then experimentally investigated the permeation rate of solutes (Na, K and Cl) through the fibrotic tissue using a microfluidic device, and found that diffusion coefficients with respect to all the solutions were on the order of 10-10 m2/s, which increased with the flow rates.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1267-1269
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012 Jan 1
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 2012 Oct 282012 Nov 1

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12/10/2812/11/1

Keywords

  • Biocompatible packaging
  • Diffusion
  • Fibrotic tissue

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Ito, H., Prihandana, G. S., Tanimura, K., Hori, Y., Soykan, O., Sudo, R., & Miki, N. (2012). Solute diffusion through the fibrotic tissue formed around a protective cage system for implantable sensors. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 1267-1269). (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012). Chemical and Biological Microsystems Society.