Sonodynamic therapy decreased neointimal hyperplasia after stenting in the rabbit iliac artery

Koh Arakawa, Kousukue Hagisawa, Hiroyuki Kusano, Satoru Yoneyama, Akira Kurita, Tsunenori Arai, Makoto Kikuchi, Isao Sakata, Shin Ichirou Umenura, Fumitaka Ohsuzu

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27 Citations (Scopus)

Abstract

Background - In-stent restenosis remains a pivotal problem after coronary and peripheral stenting. Sonodynamic therapy inhibits tumor growth by means of cytotoxicity after the activation of sonochemical sensitizers by ultrasound. PAD-S31 is known to be a water-soluble, chlorin-derivative sonochemical sensitizer. We assessed the efficacy of sonodynamic therapy using this sensitizer on neointimal hyperplasia in a rabbit stent model. Methods and Results - Stents were implanted in the iliac arteries of 16 rabbits. A total of 32 stented arteries were randomized to sonodynamic therapy, control, ultrasound exposure, and PAD-S31 groups. One hour after the intravenous administration of PAD-S31 (25 mg/kg body weight), ultrasound energy (1 MHz, 0.3 W/cm2) was delivered transdermally to the sonodynamic therapy group. At 28 days, all stent sites were analyzed morphometrically. The size of the intimal cross-sectional area was smaller in the sonodynamic therapy group than in the control, ultrasound, and PAD-S31 groups (0.31±0.07 versus 1.38±0.47, 1.66±0.71, and 1.61±0.42 mm2, respectively; P <0.05). The ratio of the intimal and medial cross-sectional area was smaller in the sonodynamic therapy group than in the control, ultrasound, and PAD-S31 groups (0.71±0.22 versus 2.53±1.39, 2.48±0.60, and 3.45±1.42 mm2; P <0.05). Conclusions - Sonodynamic therapy with PAD-S31 is considered to be a feasible treatment modality for noninvasively inhibiting neointimal hyperplasia in a rabbit iliac stent model.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalCirculation
Volume105
Issue number2
DOIs
Publication statusPublished - 2002 Jan 15

Keywords

  • Restenosis
  • Sonodynamic therapy
  • Stents
  • Ultrasonics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Arakawa, K., Hagisawa, K., Kusano, H., Yoneyama, S., Kurita, A., Arai, T., Kikuchi, M., Sakata, I., Umenura, S. I., & Ohsuzu, F. (2002). Sonodynamic therapy decreased neointimal hyperplasia after stenting in the rabbit iliac artery. Circulation, 105(2), 149-151. https://doi.org/10.1161/hc0202.102921