Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1

Hiroyuki Ohba, Tatsuyuki Chiyoda, Emmy Endo, Masato Yano, Yoshika Hayakawa, Masanori Sakaguchi, Robert B. Darnell, Hirotaka J. Okano, Hideyuki Okano

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Sox21, a high-mobility group box transcription factor, is expressed throughout the immature neural stem/progenitor population in ventricular zone but not in the cortical plate in embryonic mouse brain and its expression is restricted to the subventricular zone in the adult brain. In undifferentiated PC12 cells, endogenous Sox21 expression is detected but its expression ceases during the nerve growth factor (NGF)-induced neuronal differentiation. Overexpression of Sox21 results in a substantial repression of NGF-induced neurite outgrowth in PC12 cells. Further, we biochemically identified a Sox21-associating protein, Y-box binding protein 1 which not only binds to Sox21 but also partially restores NGF-induced neurite outgrowth of PC12 cells inhibited by Sox21. These results suggest that Sox21 is a repressor of neuronal differentiation in the developing nervous system.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalNeuroscience Letters
Volume358
Issue number3
DOIs
Publication statusPublished - 2004 Apr 1

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Keywords

  • Development
  • Neural stem cells
  • Neurite outgrowth
  • Sox21
  • Transcription factor
  • Y-box binding protein 1

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ohba, H., Chiyoda, T., Endo, E., Yano, M., Hayakawa, Y., Sakaguchi, M., Darnell, R. B., Okano, H. J., & Okano, H. (2004). Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1. Neuroscience Letters, 358(3), 157-160. https://doi.org/10.1016/j.neulet.2004.01.026