Spatial-sweep steady-state pattern electroretinography can detect subtle differences in visual function among healthy adults

Sakiko Minami, Norihiro Nagai, Misa Suzuki, Toshihide Kurihara, Hideki Sonobe, Kazuhiro Watanabe, Hajime Shinoda, Hitoshi Takagi, Kazuo Tsubota, Yoko Ozawa

Research output: Contribution to journalArticle

Abstract

We aimed to establish a highly sensitive method for measuring visual function using spatial-sweep steady-state pattern electroretinography (swpPERG). Overall, 35 eyes of 35 healthy adults (18 men; mean age, 32.3 years) were examined using swpPERG, and the data were recorded using spatial-patterned and contrast-reversed stimuli of size 1 (thickest) to 6. Data were converted into frequency-domain using a Fourier transform and expressed by signal-to-noise ratio (SNR). The number of participants who showed SNR ≥ 1 was significantly lesser at stimulus sizes 5 and 6 compared with those at greater stimulus sizes. Among the data with SNR ≥ 1, SNRs were negatively correlated with age at stimulus size 5 (r = −0.500, P = 0.029), and positively correlated with macular volume evaluated by optical coherence tomography (OCT) within a 6-mm circle diameter from the fovea of the retinal nerve fibre layer at size 4 (r = 0.409, P = 0.025) and of the ganglion cell layer at size 5 (r = 0.567, P = 0.011). We found that SNRs of swpPERG, recorded using the EvokeDx system, were correlated with age and macular morphology in participants without diagnosed eye diseases. The system detected subtle differences in retinal function, which may help in early disease diagnosis and visual evaluation in neuroprotective interventions in the future.

Original languageEnglish
Article number18119
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

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Electroretinography
Signal-To-Noise Ratio
Eye Diseases
Optical Coherence Tomography
Fourier Analysis
Nerve Fibers
Ganglia
Early Diagnosis

ASJC Scopus subject areas

  • General

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Spatial-sweep steady-state pattern electroretinography can detect subtle differences in visual function among healthy adults. / Minami, Sakiko; Nagai, Norihiro; Suzuki, Misa; Kurihara, Toshihide; Sonobe, Hideki; Watanabe, Kazuhiro; Shinoda, Hajime; Takagi, Hitoshi; Tsubota, Kazuo; Ozawa, Yoko.

In: Scientific reports, Vol. 9, No. 1, 18119, 01.12.2019.

Research output: Contribution to journalArticle

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