Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis

Kuniaki Mukai, Hiroshi Sugimoto, Katsumasa Kamiya, Reiko Suzuki, Tomomi Matsuura, Takako Hishiki, Hideo Shimada, Yoshitsugu Shiro, Makoto Suematsu, Norio Kagawa

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Medicine & Life Sciences