TY - JOUR
T1 - “Spike” in acute asthma exacerbations during enterovirus D68 epidemic in Japan
T2 - A nation-wide survey
AU - on behalf of the Japanese Society of Pediatric Allergy and Clinical Immunology
AU - Korematsu, Seigo
AU - Nagashima, Kengo
AU - Sato, Yasunori
AU - Nagao, Mizuho
AU - Hasegawa, Shunji
AU - Nakamura, Haruna
AU - Sugiura, Shiro
AU - Miura, Katsushi
AU - Okada, Kenji
AU - Fujisawa, Takao
AU - the Japanese Society of Pediatric Allergy, Japanese Society of Pediatric Allergy
N1 - Funding Information:
The authors would like to thank the doctors at the 157 hospitals in Japan for their prompt cooperation in providing the valuable data for this survey, Dr. Keiko Taya and Dr. Kazunori Oishi at the National Institute of Infectious Diseases Surveillance Center for providing important advice and national surveillance data, and Dr. Kiyosu Taniguchi at the Institute for Clinical Research Mie National Hospital for valuable comments and critical information. The study was supported by the Japanese Society of Pediatric Allergy and Clinical Immunology. The Board of Directors of JSPACI decided to perform this study and offered critical comments regarding its conduct.
PY - 2018/1
Y1 - 2018/1
N2 - Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.
AB - Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.
KW - Asthma exacerbation
KW - Bronchial asthma
KW - Enterovirus D68
KW - Nation-wide survey
KW - Pediatrics
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U2 - 10.1016/j.alit.2017.04.003
DO - 10.1016/j.alit.2017.04.003
M3 - Article
C2 - 28455155
AN - SCOPUS:85018671824
VL - 67
SP - 55
EP - 60
JO - Allergology International
JF - Allergology International
SN - 1323-8930
IS - 1
ER -