Abstract
Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.
| Original language | English |
|---|---|
| Pages (from-to) | 55-60 |
| Number of pages | 6 |
| Journal | Allergology International |
| Volume | 67 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
| Externally published | Yes |
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Keywords
- Asthma exacerbation
- Bronchial asthma
- Enterovirus D68
- Nation-wide survey
- Pediatrics
ASJC Scopus subject areas
- Immunology and Allergy
Cite this
“Spike” in acute asthma exacerbations during enterovirus D68 epidemic in Japan : A nation-wide survey. / on behalf of the Japanese Society of Pediatric Allergy and Clinical Immunology.
In: Allergology International, Vol. 67, No. 1, 01.01.2018, p. 55-60.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - “Spike” in acute asthma exacerbations during enterovirus D68 epidemic in Japan
T2 - A nation-wide survey
AU - on behalf of the Japanese Society of Pediatric Allergy and Clinical Immunology
AU - Korematsu, Seigo
AU - Nagashima, Kengo
AU - Sato, Yasunori
AU - Nagao, Mizuho
AU - Hasegawa, Shunji
AU - Nakamura, Haruna
AU - Sugiura, Shiro
AU - Miura, Katsushi
AU - Okada, Kenji
AU - Fujisawa, Takao
AU - the Japanese Society of Pediatric Allergy, Japanese Society of Pediatric Allergy
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.
AB - Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.
KW - Asthma exacerbation
KW - Bronchial asthma
KW - Enterovirus D68
KW - Nation-wide survey
KW - Pediatrics
UR - http://www.scopus.com/inward/record.url?scp=85018671824&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018671824&partnerID=8YFLogxK
U2 - 10.1016/j.alit.2017.04.003
DO - 10.1016/j.alit.2017.04.003
M3 - Article
VL - 67
SP - 55
EP - 60
JO - Allergology International
JF - Allergology International
SN - 1323-8930
IS - 1
ER -