“Spike” in acute asthma exacerbations during enterovirus D68 epidemic in Japan

A nation-wide survey

on behalf of the Japanese Society of Pediatric Allergy and Clinical Immunology

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalAllergology International
Volume67
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Fingerprint

Enterovirus
Japan
Asthma
Hospitalization
Artificial Respiration
Causality
Communicable Diseases
Surveys and Questionnaires
Pediatrics
Bronchitis
Allergy and Immunology
Age Groups
Databases

Keywords

  • Asthma exacerbation
  • Bronchial asthma
  • Enterovirus D68
  • Nation-wide survey
  • Pediatrics

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

“Spike” in acute asthma exacerbations during enterovirus D68 epidemic in Japan : A nation-wide survey. / on behalf of the Japanese Society of Pediatric Allergy and Clinical Immunology.

In: Allergology International, Vol. 67, No. 1, 01.01.2018, p. 55-60.

Research output: Contribution to journalArticle

on behalf of the Japanese Society of Pediatric Allergy and Clinical Immunology 2018, '“Spike” in acute asthma exacerbations during enterovirus D68 epidemic in Japan: A nation-wide survey', Allergology International, vol. 67, no. 1, pp. 55-60. https://doi.org/10.1016/j.alit.2017.04.003
on behalf of the Japanese Society of Pediatric Allergy and Clinical Immunology. / “Spike” in acute asthma exacerbations during enterovirus D68 epidemic in Japan : A nation-wide survey. In: Allergology International. 2018 ; Vol. 67, No. 1. pp. 55-60.
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title = "“Spike” in acute asthma exacerbations during enterovirus D68 epidemic in Japan: A nation-wide survey",
abstract = "Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.",
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author = "{on behalf of the Japanese Society of Pediatric Allergy and Clinical Immunology} and Seigo Korematsu and Kengo Nagashima and Yasunori Sato and Mizuho Nagao and Shunji Hasegawa and Haruna Nakamura and Shiro Sugiura and Katsushi Miura and Kenji Okada and Takao Fujisawa and {the Japanese Society of Pediatric Allergy}, {Japanese Society of Pediatric Allergy}",
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T1 - “Spike” in acute asthma exacerbations during enterovirus D68 epidemic in Japan

T2 - A nation-wide survey

AU - on behalf of the Japanese Society of Pediatric Allergy and Clinical Immunology

AU - Korematsu, Seigo

AU - Nagashima, Kengo

AU - Sato, Yasunori

AU - Nagao, Mizuho

AU - Hasegawa, Shunji

AU - Nakamura, Haruna

AU - Sugiura, Shiro

AU - Miura, Katsushi

AU - Okada, Kenji

AU - Fujisawa, Takao

AU - the Japanese Society of Pediatric Allergy, Japanese Society of Pediatric Allergy

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N2 - Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.

AB - Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.

KW - Asthma exacerbation

KW - Bronchial asthma

KW - Enterovirus D68

KW - Nation-wide survey

KW - Pediatrics

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