Abstract
Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.
| Original language | English |
|---|---|
| Pages (from-to) | 1203-1210 |
| Number of pages | 8 |
| Journal | Magnetic Resonance Imaging |
| Volume | 17 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1999 Oct |
| Externally published | Yes |
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Keywords
- H MRS
- Echo planar imaging (EPI)
- Lipids
ASJC Scopus subject areas
- Biophysics
- Clinical Biochemistry
- Structural Biology
- Radiology Nuclear Medicine and imaging
- Condensed Matter Physics
Cite this
Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow. / Bao, Sumi; Guttmann, Charles R G; Mugler, John P.; Brookeman, James R.; Panych, Lawrence P.; Kraft, Robert A.; Oshio, Koichi; Jaramillo, Diego; Jolesz, Ferenc A.; Williamson, Daniel S.; Mulkern, Robert V.
In: Magnetic Resonance Imaging, Vol. 17, No. 8, 10.1999, p. 1203-1210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow
AU - Bao, Sumi
AU - Guttmann, Charles R G
AU - Mugler, John P.
AU - Brookeman, James R.
AU - Panych, Lawrence P.
AU - Kraft, Robert A.
AU - Oshio, Koichi
AU - Jaramillo, Diego
AU - Jolesz, Ferenc A.
AU - Williamson, Daniel S.
AU - Mulkern, Robert V.
PY - 1999/10
Y1 - 1999/10
N2 - Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.
AB - Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.
KW - H MRS
KW - Echo planar imaging (EPI)
KW - Lipids
UR - http://www.scopus.com/inward/record.url?scp=0032877896&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032877896&partnerID=8YFLogxK
U2 - 10.1016/S0730-725X(99)00056-9
DO - 10.1016/S0730-725X(99)00056-9
M3 - Article
C2 - 10499682
AN - SCOPUS:0032877896
VL - 17
SP - 1203
EP - 1210
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 8
ER -