Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow

Sumi Bao; Charles R.G. Guttmann; John P. Mugler; James R. Brookeman; Lawrence P. Panych; Robert A. Kraft; Koichi Oshio; Diego Jaramillo; Ferenc A. Jolesz; Daniel S. Williamson; Robert V. Mulkern

doi:10.1016/S0730-725X(99)00056-9

Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow

Sumi Bao, Charles R.G. Guttmann, John P. Mugler, James R. Brookeman, Lawrence P. Panych, Robert A. Kraft, Koichi Oshio, Diego Jaramillo, Ferenc A. Jolesz, Daniel S. Williamson, Robert V. Mulkern

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.

Original language	English
Pages (from-to)	1203-1210
Number of pages	8
Journal	Magnetic Resonance Imaging
Volume	17
Issue number	8
DOIs	https://doi.org/10.1016/S0730-725X(99)00056-9
Publication status	Published - 1999 Oct
Externally published	Yes

Keywords

Echo planar imaging (EPI)
H MRS
Lipids

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

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10.1016/S0730-725X(99)00056-9

Cite this

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title = "Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow",

abstract = "Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.",

keywords = "Echo planar imaging (EPI), H MRS, Lipids",

author = "Sumi Bao and Guttmann, {Charles R.G.} and Mugler, {John P.} and Brookeman, {James R.} and Panych, {Lawrence P.} and Kraft, {Robert A.} and Koichi Oshio and Diego Jaramillo and Jolesz, {Ferenc A.} and Williamson, {Daniel S.} and Mulkern, {Robert V.}",

note = "Funding Information: This work was supported in part by National Institute of Health award RO1 NS-35142.",

year = "1999",

month = oct,

doi = "10.1016/S0730-725X(99)00056-9",

language = "English",

volume = "17",

pages = "1203--1210",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow

AU - Bao, Sumi

AU - Guttmann, Charles R.G.

AU - Mugler, John P.

AU - Brookeman, James R.

AU - Panych, Lawrence P.

AU - Kraft, Robert A.

AU - Oshio, Koichi

AU - Jaramillo, Diego

AU - Jolesz, Ferenc A.

AU - Williamson, Daniel S.

AU - Mulkern, Robert V.

N1 - Funding Information: This work was supported in part by National Institute of Health award RO1 NS-35142.

PY - 1999/10

Y1 - 1999/10

N2 - Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.

AB - Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.

KW - Echo planar imaging (EPI)

KW - H MRS

KW - Lipids

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UR - http://www.scopus.com/inward/citedby.url?scp=0032877896&partnerID=8YFLogxK

U2 - 10.1016/S0730-725X(99)00056-9

DO - 10.1016/S0730-725X(99)00056-9

M3 - Article

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AN - SCOPUS:0032877896

VL - 17

SP - 1203

EP - 1210

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

IS - 8

ER -

Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow

Abstract

Keywords

ASJC Scopus subject areas

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