Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow

Sumi Bao; Charles R.G. Guttmann; John P. Mugler; James R. Brookeman; Lawrence P. Panych; Robert A. Kraft; Koichi Oshio; Diego Jaramillo; Ferenc A. Jolesz; Daniel S. Williamson; Robert V. Mulkern

doi:10.1016/S0730-725X(99)00056-9

Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow

Sumi Bao, Charles R.G. Guttmann, John P. Mugler, James R. Brookeman, Lawrence P. Panych, Robert A. Kraft, Koichi Oshio, Diego Jaramillo, Ferenc A. Jolesz, Daniel S. Williamson, Robert V. Mulkern

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.

Original language	English
Pages (from-to)	1203-1210
Number of pages	8
Journal	Magnetic Resonance Imaging
Volume	17
Issue number	8
DOIs	https://doi.org/10.1016/S0730-725X(99)00056-9
Publication status	Published - 1999 Oct
Externally published	Yes

Keywords

Echo planar imaging (EPI)
H MRS
Lipids

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

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Bao, S., Guttmann, C. R. G., Mugler, J. P., Brookeman, J. R., Panych, L. P., Kraft, R. A., Oshio, K., Jaramillo, D., Jolesz, F. A., Williamson, D. S., & Mulkern, R. V. (1999). Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow. Magnetic Resonance Imaging, 17(8), 1203-1210. https://doi.org/10.1016/S0730-725X(99)00056-9

Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow. / Bao, Sumi; Guttmann, Charles R.G.; Mugler, John P.; Brookeman, James R.; Panych, Lawrence P.; Kraft, Robert A.; Oshio, Koichi; Jaramillo, Diego; Jolesz, Ferenc A.; Williamson, Daniel S.; Mulkern, Robert V.

In: Magnetic Resonance Imaging, Vol. 17, No. 8, 10.1999, p. 1203-1210.

Research output: Contribution to journal › Article

Bao, Sumi ; Guttmann, Charles R.G. ; Mugler, John P. ; Brookeman, James R. ; Panych, Lawrence P. ; Kraft, Robert A. ; Oshio, Koichi ; Jaramillo, Diego ; Jolesz, Ferenc A. ; Williamson, Daniel S. ; Mulkern, Robert V. / Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow. In: Magnetic Resonance Imaging. 1999 ; Vol. 17, No. 8. pp. 1203-1210.

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abstract = "Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.",

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AU - Bao, Sumi

AU - Guttmann, Charles R.G.

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AU - Kraft, Robert A.

AU - Oshio, Koichi

AU - Jaramillo, Diego

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AU - Williamson, Daniel S.

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AB - Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.

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KW - H MRS

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