Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow

Sumi Bao, Charles R G Guttmann, John P. Mugler, James R. Brookeman, Lawrence P. Panych, Robert A. Kraft, Koichi Oshio, Diego Jaramillo, Ferenc A. Jolesz, Daniel S. Williamson, Robert V. Mulkern

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.

Original languageEnglish
Pages (from-to)1203-1210
Number of pages8
JournalMagnetic Resonance Imaging
Volume17
Issue number8
DOIs
Publication statusPublished - 1999 Oct
Externally publishedYes

Fingerprint

Echo-Planar Imaging
bone marrow
Lipids
lipids
echoes
Bone
Bone Marrow
Imaging techniques
Magnetic resonance spectroscopy
proton magnetic resonance
magnetic resonance spectroscopy
chemical equilibrium
acquisition
Healthy Volunteers
Oils
chemical composition
Triglycerides
spatial resolution
oils
Magnetic Resonance Imaging

Keywords

  • H MRS
  • Echo planar imaging (EPI)
  • Lipids

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Bao, S., Guttmann, C. R. G., Mugler, J. P., Brookeman, J. R., Panych, L. P., Kraft, R. A., ... Mulkern, R. V. (1999). Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow. Magnetic Resonance Imaging, 17(8), 1203-1210. https://doi.org/10.1016/S0730-725X(99)00056-9

Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow. / Bao, Sumi; Guttmann, Charles R G; Mugler, John P.; Brookeman, James R.; Panych, Lawrence P.; Kraft, Robert A.; Oshio, Koichi; Jaramillo, Diego; Jolesz, Ferenc A.; Williamson, Daniel S.; Mulkern, Robert V.

In: Magnetic Resonance Imaging, Vol. 17, No. 8, 10.1999, p. 1203-1210.

Research output: Contribution to journalArticle

Bao, S, Guttmann, CRG, Mugler, JP, Brookeman, JR, Panych, LP, Kraft, RA, Oshio, K, Jaramillo, D, Jolesz, FA, Williamson, DS & Mulkern, RV 1999, 'Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow', Magnetic Resonance Imaging, vol. 17, no. 8, pp. 1203-1210. https://doi.org/10.1016/S0730-725X(99)00056-9
Bao, Sumi ; Guttmann, Charles R G ; Mugler, John P. ; Brookeman, James R. ; Panych, Lawrence P. ; Kraft, Robert A. ; Oshio, Koichi ; Jaramillo, Diego ; Jolesz, Ferenc A. ; Williamson, Daniel S. ; Mulkern, Robert V. / Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow. In: Magnetic Resonance Imaging. 1999 ; Vol. 17, No. 8. pp. 1203-1210.
@article{d57c45fc68a14a9abb8313ea15d884e6,
title = "Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow",
abstract = "Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.",
keywords = "H MRS, Echo planar imaging (EPI), Lipids",
author = "Sumi Bao and Guttmann, {Charles R G} and Mugler, {John P.} and Brookeman, {James R.} and Panych, {Lawrence P.} and Kraft, {Robert A.} and Koichi Oshio and Diego Jaramillo and Jolesz, {Ferenc A.} and Williamson, {Daniel S.} and Mulkern, {Robert V.}",
year = "1999",
month = "10",
doi = "10.1016/S0730-725X(99)00056-9",
language = "English",
volume = "17",
pages = "1203--1210",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow

AU - Bao, Sumi

AU - Guttmann, Charles R G

AU - Mugler, John P.

AU - Brookeman, James R.

AU - Panych, Lawrence P.

AU - Kraft, Robert A.

AU - Oshio, Koichi

AU - Jaramillo, Diego

AU - Jolesz, Ferenc A.

AU - Williamson, Daniel S.

AU - Mulkern, Robert V.

PY - 1999/10

Y1 - 1999/10

N2 - Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.

AB - Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.

KW - H MRS

KW - Echo planar imaging (EPI)

KW - Lipids

UR - http://www.scopus.com/inward/record.url?scp=0032877896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032877896&partnerID=8YFLogxK

U2 - 10.1016/S0730-725X(99)00056-9

DO - 10.1016/S0730-725X(99)00056-9

M3 - Article

C2 - 10499682

AN - SCOPUS:0032877896

VL - 17

SP - 1203

EP - 1210

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

IS - 8

ER -