Spinal kyphosis causes demyelination and neuronal loss in the spinal cord

Masaya Nakamura, Kentaro Shimizu, Yoshiaki Toyama

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The spinal cord has remarkable ability to resist chronic compression; however, delayed paralysis is sometimes seen following the development of spinal kyphosis. In the past, no animal model to clarify the mechanism of spinal cord damage due to spinal kyphotic deformity has been available. We developed a new experimental model of chronic spinal cord compression using a bird, to evaluate the effects of chronic compression associated with kyphotic deformity of the cervical spine on the spinal cord. As kyphosis progressed, the spinal cord flattening became more marked, causing histopathological changes, including demyelination and neuronal loss. Demyelination of the axons progressed in the order of the anterior, lateral, and then posterior funiculus. Furthermore, microangiography suggested that vascular disturbance in addition to mechanical compression may have contributed to the development of histological changes. In conclusion, progressive kyphosis of the cervical spine resulted in demyelination of nerve fibers in the funiculi and neuronal loss in the anterior horn due to chronic compression of the spinal cord. These histological changes seem to be associated with both continuous mechanical compression and vascular changes in the spinal cord.

Original languageEnglish
Title of host publicationNeuroprotection and Regeneration of the Spinal Cord
PublisherSpringer Japan
Pages129-138
Number of pages10
Volume9784431545026
ISBN (Print)9784431545026, 4431545018, 9784431545019
DOIs
Publication statusPublished - 2013 Nov 1

Fingerprint

Kyphosis
Demyelinating Diseases
Spinal Cord
Spinal Cord Compression
Blood Vessels
Spine
Horns
Nerve Fibers
Paralysis
Birds
Axons
Theoretical Models
Animal Models

Keywords

  • Cervical spine
  • Chronic compression
  • Kyphotic deformity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nakamura, M., Shimizu, K., & Toyama, Y. (2013). Spinal kyphosis causes demyelination and neuronal loss in the spinal cord. In Neuroprotection and Regeneration of the Spinal Cord (Vol. 9784431545026, pp. 129-138). Springer Japan. https://doi.org/10.1007/978-4-431-54502-6_12

Spinal kyphosis causes demyelination and neuronal loss in the spinal cord. / Nakamura, Masaya; Shimizu, Kentaro; Toyama, Yoshiaki.

Neuroprotection and Regeneration of the Spinal Cord. Vol. 9784431545026 Springer Japan, 2013. p. 129-138.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nakamura, M, Shimizu, K & Toyama, Y 2013, Spinal kyphosis causes demyelination and neuronal loss in the spinal cord. in Neuroprotection and Regeneration of the Spinal Cord. vol. 9784431545026, Springer Japan, pp. 129-138. https://doi.org/10.1007/978-4-431-54502-6_12
Nakamura M, Shimizu K, Toyama Y. Spinal kyphosis causes demyelination and neuronal loss in the spinal cord. In Neuroprotection and Regeneration of the Spinal Cord. Vol. 9784431545026. Springer Japan. 2013. p. 129-138 https://doi.org/10.1007/978-4-431-54502-6_12
Nakamura, Masaya ; Shimizu, Kentaro ; Toyama, Yoshiaki. / Spinal kyphosis causes demyelination and neuronal loss in the spinal cord. Neuroprotection and Regeneration of the Spinal Cord. Vol. 9784431545026 Springer Japan, 2013. pp. 129-138
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