Spindle-shaped constriction and propagated dilation of arterioles during cortical spreading depression

Takashi Osada, Minoru Tomita, Norihiro Suzuki

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A dual illumination technique was used to examine the behavior of parenchymal arterioles of the cortex during cortical spreading depression in six cats. K+ produced a wave-ring spread of optical density changes concentrically from the injection site. At locations where the wave was passing, arterioles first constricted at one or two spots (55±43% of control), forming a spindle-shape in the early phase of cortical spreading depression, and then markedly dilated (155±57% of control) within 1 min. The dilation started at the constricted spots, propagated bidirectionally and finally resulted in full-length dilation of the arteriole. Although it varied in magnitude and time-course, this arteriolar behavior was observed in all six cats. Despite these changes, no associated downstream tissue microvascular flow changes were discernable.

Original languageEnglish
Pages (from-to)1365-1368
Number of pages4
JournalNeuroReport
Volume17
Issue number12
DOIs
Publication statusPublished - 2006 Aug 1

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Keywords

  • Cat
  • Cortical spreading depression
  • Dual illumination technique
  • Gyrencephala
  • Oligemia
  • Parenchymal arteriole
  • Potassium
  • Propagated dilation
  • Spindle-shaped string contraction

ASJC Scopus subject areas

  • Neuroscience(all)

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