Spiro bis(isoxazole) as a new chiral ligand

Kazuhiko Wakita, Midori A. Arai, Takahiro Kato, Toshio Shinohara, Hiroaki Sasai

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


A novel bis(isoxazole) ligand, (M*)-4,4′,5,5′,6,6′ ,7,7′-octahydro-7,7′-spirobi[benzo[c]isoxazole] (5) bearing a spiro chirality was designed and synthesized. Characterization of the ligand and its application to the enantioselective tandem cyclizaton of alkenyl alcohol via oxy-palladation are described.

Original languageEnglish
Pages (from-to)831-838
Number of pages8
Publication statusPublished - 2004 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


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