Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation

Takaya Murakami, Xin Chen, Kouji Hase, Ayako Sakamoto, Chie Nishigaki, Hiroshi Ohno

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Follicular dendritic cells (FDCs) form a reticular FDC network in the lymphoid follicle that is essential for the retention and presentation of native antigens in the form of antigen-antibody immune complexes (ICs) to B cells during secondary immune response. Although the presence of migrating precursors of FDCs has been hypothesized, their entity has not been elucidated. Here we report the identification of murine splenic CD19-CD11c -CD35+B220+ cells as an inducer of FDC network formation. We demonstrated that CD19--CD11c-CD35 +B220+ cells, together with stromal cells, had the remarkable ability to form lymphoid-follicle-like structures that contained B220+FDC-M1+ reticular cells originally derived from CD19--CD11c-CD35+B220+ cells in the CD35+ reticulum. Our results indicate that CD19-CD11c -CD35+B220+ cells function as an inducer of FDC network formation and that the interaction between CD19-CD11c -CD35+B220+ cells and stromal cells is required to initiate lymphoid follicle formation.

Original languageEnglish
Pages (from-to)1215-1224
Number of pages10
JournalBlood
Volume110
Issue number4
DOIs
Publication statusPublished - 2007 Aug 15
Externally publishedYes

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Follicular Dendritic Cells
Stromal Cells
Antigen-Antibody Complex
Antigens
Reticulum
Antigen Presentation
Helper-Inducer T-Lymphocytes
Dendritic Cells
B-Lymphocytes
Cells
Antibodies

ASJC Scopus subject areas

  • Hematology

Cite this

Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation. / Murakami, Takaya; Chen, Xin; Hase, Kouji; Sakamoto, Ayako; Nishigaki, Chie; Ohno, Hiroshi.

In: Blood, Vol. 110, No. 4, 15.08.2007, p. 1215-1224.

Research output: Contribution to journalArticle

Murakami, Takaya ; Chen, Xin ; Hase, Kouji ; Sakamoto, Ayako ; Nishigaki, Chie ; Ohno, Hiroshi. / Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation. In: Blood. 2007 ; Vol. 110, No. 4. pp. 1215-1224.
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AU - Hase, Kouji

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AU - Nishigaki, Chie

AU - Ohno, Hiroshi

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