Split Genes

K. Fujishima, Akio Kanai

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Genomic and transcriptomic analyses have revealed an unexpected complexity of genes in diverse living organisms. In eukaryotes, most protein-coding genes are interrupted by intronic sequences, which split the genes into multiple exons. Most of these genes undergo a process called 'alternative splicing', in which cis-encoded exons are joined in different combinations to produce various messenger RNAs (mRNAs). Some eukaryotic mRNAs and archaeal tRNAs are produced by the trans-splicing of multiple transcripts expressed from distinct genes. In this article, we introduce the different modes of gene splitting found in the Eukaryotes and the Archaea and discuss their possible roles in biological systems.

Original languageEnglish
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages543-544
Number of pages2
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
Publication statusPublished - 2013 Feb 27

Fingerprint

Genes
Eukaryota
genes
messenger RNA
Exons
exons
Trans-Splicing
eukaryotic cells
Messenger RNA
trans-splicing
Archaea
Alternative Splicing
Transfer RNA
alternative splicing
Biological systems
transcriptomics
genomics
organisms
Proteins
proteins

Keywords

  • Alternative splicing
  • Exon
  • Intron
  • RNA-splicing endonuclease
  • Trans-splicing

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Fujishima, K., & Kanai, A. (2013). Split Genes. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 543-544). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.01467-4

Split Genes. / Fujishima, K.; Kanai, Akio.

Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., 2013. p. 543-544.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fujishima, K & Kanai, A 2013, Split Genes. in Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., pp. 543-544. https://doi.org/10.1016/B978-0-12-374984-0.01467-4
Fujishima K, Kanai A. Split Genes. In Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc. 2013. p. 543-544 https://doi.org/10.1016/B978-0-12-374984-0.01467-4
Fujishima, K. ; Kanai, Akio. / Split Genes. Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., 2013. pp. 543-544
@inbook{2e2c8182ced44c32907539ed90510468,
title = "Split Genes",
abstract = "Genomic and transcriptomic analyses have revealed an unexpected complexity of genes in diverse living organisms. In eukaryotes, most protein-coding genes are interrupted by intronic sequences, which split the genes into multiple exons. Most of these genes undergo a process called 'alternative splicing', in which cis-encoded exons are joined in different combinations to produce various messenger RNAs (mRNAs). Some eukaryotic mRNAs and archaeal tRNAs are produced by the trans-splicing of multiple transcripts expressed from distinct genes. In this article, we introduce the different modes of gene splitting found in the Eukaryotes and the Archaea and discuss their possible roles in biological systems.",
keywords = "Alternative splicing, Exon, Intron, RNA-splicing endonuclease, Trans-splicing",
author = "K. Fujishima and Akio Kanai",
year = "2013",
month = "2",
day = "27",
doi = "10.1016/B978-0-12-374984-0.01467-4",
language = "English",
isbn = "9780123749840",
pages = "543--544",
booktitle = "Brenner's Encyclopedia of Genetics",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Split Genes

AU - Fujishima, K.

AU - Kanai, Akio

PY - 2013/2/27

Y1 - 2013/2/27

N2 - Genomic and transcriptomic analyses have revealed an unexpected complexity of genes in diverse living organisms. In eukaryotes, most protein-coding genes are interrupted by intronic sequences, which split the genes into multiple exons. Most of these genes undergo a process called 'alternative splicing', in which cis-encoded exons are joined in different combinations to produce various messenger RNAs (mRNAs). Some eukaryotic mRNAs and archaeal tRNAs are produced by the trans-splicing of multiple transcripts expressed from distinct genes. In this article, we introduce the different modes of gene splitting found in the Eukaryotes and the Archaea and discuss their possible roles in biological systems.

AB - Genomic and transcriptomic analyses have revealed an unexpected complexity of genes in diverse living organisms. In eukaryotes, most protein-coding genes are interrupted by intronic sequences, which split the genes into multiple exons. Most of these genes undergo a process called 'alternative splicing', in which cis-encoded exons are joined in different combinations to produce various messenger RNAs (mRNAs). Some eukaryotic mRNAs and archaeal tRNAs are produced by the trans-splicing of multiple transcripts expressed from distinct genes. In this article, we introduce the different modes of gene splitting found in the Eukaryotes and the Archaea and discuss their possible roles in biological systems.

KW - Alternative splicing

KW - Exon

KW - Intron

KW - RNA-splicing endonuclease

KW - Trans-splicing

UR - http://www.scopus.com/inward/record.url?scp=85043241750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043241750&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374984-0.01467-4

DO - 10.1016/B978-0-12-374984-0.01467-4

M3 - Chapter

AN - SCOPUS:85043241750

SN - 9780123749840

SP - 543

EP - 544

BT - Brenner's Encyclopedia of Genetics

PB - Elsevier Inc.

ER -