Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co- glycolic acid nano-fiber scaffold

Koshiro Sonomoto, Kunihiro Yamaoka, Hiroaki Kaneko, Kaoru Yamagata, Kei Sakata, Xiangmei Zhang, Masahiro Kondo, Yukichi Zenke, Ken Sabanai, Shingo Nakayamada, Akinori Sakai, Yoshiya Tanaka

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) have immunosuppressive activity and can differentiate into bone and cartilage; and thus seem ideal for treatment of rheumatoid arthritis (RA). Here, we investigated the osteogenesis and chondrogenesis potentials of MSCs seeded onto nano-fiber scaffolds (NFs) in vitro and possible use for the repair of RA-affected joints.

Original languageEnglish
Article numbere0153231
JournalPLoS One
Volume11
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

Fingerprint

glycolic acid
rheumatoid arthritis
Stem cells
Mesenchymal Stromal Cells
Scaffolds
stem cells
Rheumatoid Arthritis
chondrogenesis
Chondrogenesis
immunosuppressive agents
milk
Fibers
Cartilage
Immunosuppressive Agents
bone formation
Osteogenesis
joints (animal)
cartilage
Bone
Repair

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Sonomoto, K., Yamaoka, K., Kaneko, H., Yamagata, K., Sakata, K., Zhang, X., ... Tanaka, Y. (2016). Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co- glycolic acid nano-fiber scaffold. PLoS One, 11(4), [e0153231]. https://doi.org/10.1371/journal.pone.0153231

Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co- glycolic acid nano-fiber scaffold. / Sonomoto, Koshiro; Yamaoka, Kunihiro; Kaneko, Hiroaki; Yamagata, Kaoru; Sakata, Kei; Zhang, Xiangmei; Kondo, Masahiro; Zenke, Yukichi; Sabanai, Ken; Nakayamada, Shingo; Sakai, Akinori; Tanaka, Yoshiya.

In: PLoS One, Vol. 11, No. 4, e0153231, 01.04.2016.

Research output: Contribution to journalArticle

Sonomoto, K, Yamaoka, K, Kaneko, H, Yamagata, K, Sakata, K, Zhang, X, Kondo, M, Zenke, Y, Sabanai, K, Nakayamada, S, Sakai, A & Tanaka, Y 2016, 'Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co- glycolic acid nano-fiber scaffold', PLoS One, vol. 11, no. 4, e0153231. https://doi.org/10.1371/journal.pone.0153231
Sonomoto, Koshiro ; Yamaoka, Kunihiro ; Kaneko, Hiroaki ; Yamagata, Kaoru ; Sakata, Kei ; Zhang, Xiangmei ; Kondo, Masahiro ; Zenke, Yukichi ; Sabanai, Ken ; Nakayamada, Shingo ; Sakai, Akinori ; Tanaka, Yoshiya. / Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co- glycolic acid nano-fiber scaffold. In: PLoS One. 2016 ; Vol. 11, No. 4.
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