Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co- glycolic acid nano-fiber scaffold

Koshiro Sonomoto, Kunihiro Yamaoka, Hiroaki Kaneko, Kaoru Yamagata, Kei Sakata, Xiangmei Zhang, Masahiro Kondo, Yukichi Zenke, Ken Sabanai, Shingo Nakayamada, Akinori Sakai, Yoshiya Tanaka

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28 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) have immunosuppressive activity and can differentiate into bone and cartilage; and thus seem ideal for treatment of rheumatoid arthritis (RA). Here, we investigated the osteogenesis and chondrogenesis potentials of MSCs seeded onto nano-fiber scaffolds (NFs) in vitro and possible use for the repair of RA-affected joints.

Original languageEnglish
Article numbere0153231
JournalPloS one
Volume11
Issue number4
DOIs
Publication statusPublished - 2016 Apr

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Sonomoto, K., Yamaoka, K., Kaneko, H., Yamagata, K., Sakata, K., Zhang, X., Kondo, M., Zenke, Y., Sabanai, K., Nakayamada, S., Sakai, A., & Tanaka, Y. (2016). Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co- glycolic acid nano-fiber scaffold. PloS one, 11(4), [e0153231]. https://doi.org/10.1371/journal.pone.0153231