TY - JOUR
T1 - Spontaneous lacrimal punctal occlusion associated with ocular chronic graft-versus-host disease
AU - Kamoi, Mizuka
AU - Ogawa, Yoko
AU - Dogru, Murat
AU - Uchino, Miki
AU - Kawashima, Motoko
AU - Goto, Eiki
AU - Mori, Takehiko
AU - Okamoto, Shinichiro
AU - Shimazaki, Jun
AU - Tsubota, Kazuo
N1 - Funding Information:
This study was supported in part by grants from the Japanese Ministry of Education, Science, Sports and Culture (no. 18591932).
PY - 2007/10
Y1 - 2007/10
N2 - Purpose: To investigate the clinical features of spontaneous lacrimal punctal occlusion (SLPO) after allogeneic hematopoietic stem cell transplantation (HSCT). Methods: One hundred nineteen recipients after HSCT who visited Keio University between 2001 and 2004 were examined. The condition of the lacrimal punctum, severity of dry eye, meibomian gland secretion, and presence of systemic chronic graft-versus-host disease (cGVHD) were determined with or without SLPO by retrospective chart review. Results: Among the 119 recipients, SLPO was diagnosed in 8. All the patients with SLPO after HSCT had meibomian gland dysfunction (MGD), dry eye, and systemic cGVHD. The percentage of patients with dry eye, MGD, and systemic cGVHD were significantly higher in recipients with SLPO than non-SLPO recipients (p < 0.0013, p < 0.00015, p < 0.0008, respectively). Conclusions: SLPO is a clinical presentation of ocular cGVHD and may be an indicator of the severity of dry eye and systemic cGVHD after HSCT.
AB - Purpose: To investigate the clinical features of spontaneous lacrimal punctal occlusion (SLPO) after allogeneic hematopoietic stem cell transplantation (HSCT). Methods: One hundred nineteen recipients after HSCT who visited Keio University between 2001 and 2004 were examined. The condition of the lacrimal punctum, severity of dry eye, meibomian gland secretion, and presence of systemic chronic graft-versus-host disease (cGVHD) were determined with or without SLPO by retrospective chart review. Results: Among the 119 recipients, SLPO was diagnosed in 8. All the patients with SLPO after HSCT had meibomian gland dysfunction (MGD), dry eye, and systemic cGVHD. The percentage of patients with dry eye, MGD, and systemic cGVHD were significantly higher in recipients with SLPO than non-SLPO recipients (p < 0.0013, p < 0.00015, p < 0.0008, respectively). Conclusions: SLPO is a clinical presentation of ocular cGVHD and may be an indicator of the severity of dry eye and systemic cGVHD after HSCT.
KW - Chronic graft-versus-host disease
KW - Dry eye
KW - Hematopoietic stem cell transplantation
KW - Meibomian gland dysfunction
KW - Spontaneous lacrimal punctal occlusion
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U2 - 10.1080/02713680701586409
DO - 10.1080/02713680701586409
M3 - Article
C2 - 17963103
AN - SCOPUS:35649022782
SN - 0271-3683
VL - 32
SP - 837
EP - 842
JO - Current Eye Research
JF - Current Eye Research
IS - 10
ER -