Spontaneous regression of IgG4-related dacryoadenitis

Satoru Kase, Teppei Yamamoto, Kan Ishijima, Mika Noda, Susumu Ishida

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This is the first report showing the clinical course of a patient with bilateral IgG4-related dacryoadenitis, which spontaneously regressed after excision of the left lacrimal gland. A 65-year-old female had been aware of bilateral eyelid swelling without pain for 5 years. Magnetic resonance imaging revealed enlargement of bilateral lacrimal gland. Laboratory tests showed high IgG4 concentrations, measuring 394 mg/dl. The biopsied specimen of the left lacrimal gland revealed marked lymphoplasmacytic infiltration with mild fibrosis. Marked IgG and IgG4-positive plasma cells surrounded the lymphoid follicles. Although the patient did not wish to undergo any treatments, lacrimal gland lesions showed gradual remission. This case highlights the potential of spontaneous improvement in IgG4-related dacryoadenitis, indicating that careful observation may be one of the therapeutic options for such patients.

Original languageEnglish
Pages (from-to)1018-1021
Number of pages4
JournalModern Rheumatology
Volume23
Issue number5
DOIs
Publication statusPublished - 2013 Sep
Externally publishedYes

Fingerprint

Dacryocystitis
Lacrimal Apparatus
Immunoglobulin G
Eyelids
Plasma Cells
Fibrosis
Magnetic Resonance Imaging
Observation
Pain
Therapeutics

Keywords

  • Dacryoadenitis
  • IgG4
  • Regression

ASJC Scopus subject areas

  • Rheumatology

Cite this

Kase, S., Yamamoto, T., Ishijima, K., Noda, M., & Ishida, S. (2013). Spontaneous regression of IgG4-related dacryoadenitis. Modern Rheumatology, 23(5), 1018-1021. https://doi.org/10.1007/s10165-012-0728-4

Spontaneous regression of IgG4-related dacryoadenitis. / Kase, Satoru; Yamamoto, Teppei; Ishijima, Kan; Noda, Mika; Ishida, Susumu.

In: Modern Rheumatology, Vol. 23, No. 5, 09.2013, p. 1018-1021.

Research output: Contribution to journalArticle

Kase, S, Yamamoto, T, Ishijima, K, Noda, M & Ishida, S 2013, 'Spontaneous regression of IgG4-related dacryoadenitis', Modern Rheumatology, vol. 23, no. 5, pp. 1018-1021. https://doi.org/10.1007/s10165-012-0728-4
Kase S, Yamamoto T, Ishijima K, Noda M, Ishida S. Spontaneous regression of IgG4-related dacryoadenitis. Modern Rheumatology. 2013 Sep;23(5):1018-1021. https://doi.org/10.1007/s10165-012-0728-4
Kase, Satoru ; Yamamoto, Teppei ; Ishijima, Kan ; Noda, Mika ; Ishida, Susumu. / Spontaneous regression of IgG4-related dacryoadenitis. In: Modern Rheumatology. 2013 ; Vol. 23, No. 5. pp. 1018-1021.
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