Spontaneous resolution of transfusion-associated graft-versus-host disease

S. Mori, H. Matsushita, K. Ozaki, A. Ishida, M. Tokuhira, H. Nakajima, M. Kizaki, H. Sugiura, A. Kikuchi, M. Handa, Y. Kawai, S. Yamamori, Y. Ikeda

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Abstract

Background: Transfusion-associated graft-versus-host disease (TA-GVHD) is a serious complication of blood transfusion that is characterized by high fever, a scaly maculopapular erythematous rash, diarrhea, hepatocellular damage with marked elevation of liver function test values, and pancytopenia. It can occur in immunocompetent as well as immunocompromised recipients. The existence of atypical TA-GVHD that resolves spontaneously and does not exhibit all of the manifestations has been suggested, but there has been to date no documented diagnosis of GVHD supported by evidence of engraftment. Case Report: A female patient presented and was diagnosed with acute myelogenous leukemia (AML:M4), and, after unsuccessful combination chemotherapy, she received a transfusion and developed manifestation of TA- GVHD as well as evidence of chimerism. TA-GVHD was proved by demonstrating Y chromosome-specific genes in the skin by polymerase chain reaction. The manifestations of clinical GVHD abated within 4 months. Conclusion: Polymerase chain reaction analysis of Y chromosomes in specimens from female patients is useful in the diagnosis of suspected cases of spontaneously resolving TA-GVHD.

Original languageEnglish
Pages (from-to)431-435
Number of pages5
JournalTransfusion
Volume35
Issue number5
Publication statusPublished - 1995

Fingerprint

Graft vs Host Disease
Y-Linked Genes
Polymerase Chain Reaction
Pancytopenia
Chimerism
Y Chromosome
Liver Function Tests
Exanthema
Combination Drug Therapy
Acute Myeloid Leukemia
Blood Transfusion
Diarrhea
Fever
Skin

ASJC Scopus subject areas

  • Immunology
  • Hematology

Cite this

Mori, S., Matsushita, H., Ozaki, K., Ishida, A., Tokuhira, M., Nakajima, H., ... Ikeda, Y. (1995). Spontaneous resolution of transfusion-associated graft-versus-host disease. Transfusion, 35(5), 431-435.

Spontaneous resolution of transfusion-associated graft-versus-host disease. / Mori, S.; Matsushita, H.; Ozaki, K.; Ishida, A.; Tokuhira, M.; Nakajima, H.; Kizaki, M.; Sugiura, H.; Kikuchi, A.; Handa, M.; Kawai, Y.; Yamamori, S.; Ikeda, Y.

In: Transfusion, Vol. 35, No. 5, 1995, p. 431-435.

Research output: Contribution to journalArticle

Mori, S, Matsushita, H, Ozaki, K, Ishida, A, Tokuhira, M, Nakajima, H, Kizaki, M, Sugiura, H, Kikuchi, A, Handa, M, Kawai, Y, Yamamori, S & Ikeda, Y 1995, 'Spontaneous resolution of transfusion-associated graft-versus-host disease', Transfusion, vol. 35, no. 5, pp. 431-435.
Mori S, Matsushita H, Ozaki K, Ishida A, Tokuhira M, Nakajima H et al. Spontaneous resolution of transfusion-associated graft-versus-host disease. Transfusion. 1995;35(5):431-435.
Mori, S. ; Matsushita, H. ; Ozaki, K. ; Ishida, A. ; Tokuhira, M. ; Nakajima, H. ; Kizaki, M. ; Sugiura, H. ; Kikuchi, A. ; Handa, M. ; Kawai, Y. ; Yamamori, S. ; Ikeda, Y. / Spontaneous resolution of transfusion-associated graft-versus-host disease. In: Transfusion. 1995 ; Vol. 35, No. 5. pp. 431-435.
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