@article{eef515bce2a046519c2612a45a95bf38,
title = "Spreading depression as a preclinical model of migraine",
abstract = "Spreading depression (SD) is a slowly propagating wave of near-complete depolarization of neurons and glial cells across the cortex. SD is thought to contribute to the underlying pathophysiology of migraine aura, and possibly also an intrinsic brain activity causing migraine headache. Experimental models of SD have recapitulated multiple migraine-related phenomena and are considered highly translational. In this review, we summarize conventional and novel methods to trigger SD, with specific focus on optogenetic methods. We outline physiological triggers that might affect SD susceptibility, review a multitude of physiological, biochemical, and behavioral consequences of SD, and elaborate their relevance to migraine pathophysiology. The possibility of constructing a recurrent episodic or chronic migraine model using SD is also discussed.",
keywords = "Aura, Migraine, Optogenetics, Spreading depression",
author = "Harriott, {Andrea M.} and Tsubasa Takizawa and Chung, {David Y.} and Chen, {Shih Pin}",
note = "Funding Information: This work was supported by the Brain Research Center, National Yang-Ming University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan (to SPC); Taipei Veterans General Hospital [V106C-117, V106D21–003-MY2 & V107C-089] (to SPC); Ministry of Science and Technology of Taiwan [MOST 104–2314-B-075 -006 -MY3 & MOST 107–2314-B-010-021 -] (to SPC); National Institutes of Health [KL2TR002542] (to DYC); the Phyllis and Jerome Lyle Rappaport Foundation, Building Interdisciplinary Careers in Women{\textquoteright}s Health Award [NIH, 5K12HD051959-13] (to AH), and the Training in Research for Academic Neurologists to Sustain Careers and Enhance the Numbers of Diverse Scholars (TRANSCENDS) - NINDS/NIH Award through the American Academy of Neurology [R25 NS098999-02] (to AH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2019 The Author(s).",
year = "2019",
month = may,
day = "2",
doi = "10.1186/s10194-019-1001-4",
language = "English",
volume = "20",
journal = "Journal of Headache and Pain",
issn = "1129-2369",
publisher = "Springer-Verlag Italia",
number = "1",
}