Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness

Hiromasa Inoue, Reiko Kato, Satoru Fukuyama, Atsushi Nonami, Kouji Taniguchi, Koichiro Matsumoto, Takako Nakano, Miyuki Tsuda, Mikiko Matsumura, Masato Kubo, Fumihiko Ishikawa, Byoung Gon Moon, Kiyoshi Takatsu, Yoichi Nakanishi, Akihiko Yoshimura

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

T helper 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, play a critical role in allergic asthma. These cytokines transmit signals through the Janus kinase/signal transducer and activator of transcription (STAT) and the Ras-extracellular signal-regulated kinase (ERK) signaling pathways. Although the suppressor of cytokine signaling (SOCS) family proteins have been shown to regulate the STAT pathway, the mechanism regulating the ERK pathway has not been clarified. The Sprouty-related Ena/VASP homology 1-domain-containing protein (Spred)-1 has recently been identified as a negative regulator of growth factor-mediated, Ras-dependent ERK activation. Here, using Spred-1 -deficient mice, we demonstrated that Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness, without affecting helper T cell differentiation. Biochemical assays indicate that Spred-1 suppresses IL-5-dependent cell proliferation and ERK activation. These data indicate that Spred-1 negatively controls eosinophil numbers and functions by modulating IL-5 signaling in allergic asthma.

Original languageEnglish
Pages (from-to)73-82
Number of pages10
JournalJournal of Experimental Medicine
Volume201
Issue number1
DOIs
Publication statusPublished - 2005 Jan 3
Externally publishedYes

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Extracellular Signal-Regulated MAP Kinases
Eosinophilia
Allergens
Interleukin-5
Transducers
Asthma
Suppressor of Cytokine Signaling Proteins
Cytokines
Janus Kinases
Interleukin-13
Helper-Inducer T-Lymphocytes
Eosinophils
Interleukin-4
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Cell Proliferation

ASJC Scopus subject areas

  • Immunology

Cite this

Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness. / Inoue, Hiromasa; Kato, Reiko; Fukuyama, Satoru; Nonami, Atsushi; Taniguchi, Kouji; Matsumoto, Koichiro; Nakano, Takako; Tsuda, Miyuki; Matsumura, Mikiko; Kubo, Masato; Ishikawa, Fumihiko; Moon, Byoung Gon; Takatsu, Kiyoshi; Nakanishi, Yoichi; Yoshimura, Akihiko.

In: Journal of Experimental Medicine, Vol. 201, No. 1, 03.01.2005, p. 73-82.

Research output: Contribution to journalArticle

Inoue, H, Kato, R, Fukuyama, S, Nonami, A, Taniguchi, K, Matsumoto, K, Nakano, T, Tsuda, M, Matsumura, M, Kubo, M, Ishikawa, F, Moon, BG, Takatsu, K, Nakanishi, Y & Yoshimura, A 2005, 'Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness', Journal of Experimental Medicine, vol. 201, no. 1, pp. 73-82. https://doi.org/10.1084/jem.20040616
Inoue, Hiromasa ; Kato, Reiko ; Fukuyama, Satoru ; Nonami, Atsushi ; Taniguchi, Kouji ; Matsumoto, Koichiro ; Nakano, Takako ; Tsuda, Miyuki ; Matsumura, Mikiko ; Kubo, Masato ; Ishikawa, Fumihiko ; Moon, Byoung Gon ; Takatsu, Kiyoshi ; Nakanishi, Yoichi ; Yoshimura, Akihiko. / Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness. In: Journal of Experimental Medicine. 2005 ; Vol. 201, No. 1. pp. 73-82.
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