Squalor syndrome after focal orbitofrontal damage

Michitaka Funayama, Masaru Mimura, Yuko Koshibe, Yutaka Kato

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To investigate a responsible lesion for squalor syndrome. Background: Squalor syndrome is a behavioral disorder characterized by extreme self-neglect and domestic squalor. Although frontal lobe dysfunction has been postulated to account for squalor syndrome, the relevant part of the frontal lobe has not been elucidated. MethodS: A 49-year-old housewife who suffered rupture of an anterior communicating artery aneurysm at the age of 40 years was examined using a wide range of neuropsychologic tasks. Computed tomography of the head and brain single photon emission tomography with IMP was also carried out. Results: Her performance on neuropsychologic testing was within the normal range, except for the gambling task. Computed tomography of the head showed low-density areas in the bilateral orbitofrontal cortices, basal forebrain, and right ventromedial caudate. Brain single photon emission tomography with IMP showed decreased regional cerebral blood flow in the bilateral orbitofrontal cortices and the basal forebrain. Conclusions: Our findings suggest that an orbitofrontal lesion may be responsible for squalor syndrome by leading to inappropriate decision-making and abnormal impulsivity.

Original languageEnglish
Pages (from-to)135-139
Number of pages5
JournalCognitive and Behavioral Neurology
Volume23
Issue number2
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Tomography
Inosine Monophosphate
Frontal Lobe
Prefrontal Cortex
Photons
Cerebrovascular Circulation
Head
Gambling
Impulsive Behavior
Regional Blood Flow
Brain
Intracranial Aneurysm
Rupture
Decision Making
Reference Values
Basal Forebrain

Keywords

  • Collecting behavior
  • Gambling task
  • Impulse control
  • Orbitofrontal cortex
  • Squalor syndrome

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Cognitive Neuroscience
  • Medicine(all)

Cite this

Squalor syndrome after focal orbitofrontal damage. / Funayama, Michitaka; Mimura, Masaru; Koshibe, Yuko; Kato, Yutaka.

In: Cognitive and Behavioral Neurology, Vol. 23, No. 2, 2010, p. 135-139.

Research output: Contribution to journalArticle

Funayama, Michitaka ; Mimura, Masaru ; Koshibe, Yuko ; Kato, Yutaka. / Squalor syndrome after focal orbitofrontal damage. In: Cognitive and Behavioral Neurology. 2010 ; Vol. 23, No. 2. pp. 135-139.
@article{ecf8f53ceb4147939b312cc95b453f08,
title = "Squalor syndrome after focal orbitofrontal damage",
abstract = "Objective: To investigate a responsible lesion for squalor syndrome. Background: Squalor syndrome is a behavioral disorder characterized by extreme self-neglect and domestic squalor. Although frontal lobe dysfunction has been postulated to account for squalor syndrome, the relevant part of the frontal lobe has not been elucidated. MethodS: A 49-year-old housewife who suffered rupture of an anterior communicating artery aneurysm at the age of 40 years was examined using a wide range of neuropsychologic tasks. Computed tomography of the head and brain single photon emission tomography with IMP was also carried out. Results: Her performance on neuropsychologic testing was within the normal range, except for the gambling task. Computed tomography of the head showed low-density areas in the bilateral orbitofrontal cortices, basal forebrain, and right ventromedial caudate. Brain single photon emission tomography with IMP showed decreased regional cerebral blood flow in the bilateral orbitofrontal cortices and the basal forebrain. Conclusions: Our findings suggest that an orbitofrontal lesion may be responsible for squalor syndrome by leading to inappropriate decision-making and abnormal impulsivity.",
keywords = "Collecting behavior, Gambling task, Impulse control, Orbitofrontal cortex, Squalor syndrome",
author = "Michitaka Funayama and Masaru Mimura and Yuko Koshibe and Yutaka Kato",
year = "2010",
doi = "10.1097/WNN.0b013e3181d746ba",
language = "English",
volume = "23",
pages = "135--139",
journal = "Cognitive and Behavioral Neurology",
issn = "1543-3633",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Squalor syndrome after focal orbitofrontal damage

AU - Funayama, Michitaka

AU - Mimura, Masaru

AU - Koshibe, Yuko

AU - Kato, Yutaka

PY - 2010

Y1 - 2010

N2 - Objective: To investigate a responsible lesion for squalor syndrome. Background: Squalor syndrome is a behavioral disorder characterized by extreme self-neglect and domestic squalor. Although frontal lobe dysfunction has been postulated to account for squalor syndrome, the relevant part of the frontal lobe has not been elucidated. MethodS: A 49-year-old housewife who suffered rupture of an anterior communicating artery aneurysm at the age of 40 years was examined using a wide range of neuropsychologic tasks. Computed tomography of the head and brain single photon emission tomography with IMP was also carried out. Results: Her performance on neuropsychologic testing was within the normal range, except for the gambling task. Computed tomography of the head showed low-density areas in the bilateral orbitofrontal cortices, basal forebrain, and right ventromedial caudate. Brain single photon emission tomography with IMP showed decreased regional cerebral blood flow in the bilateral orbitofrontal cortices and the basal forebrain. Conclusions: Our findings suggest that an orbitofrontal lesion may be responsible for squalor syndrome by leading to inappropriate decision-making and abnormal impulsivity.

AB - Objective: To investigate a responsible lesion for squalor syndrome. Background: Squalor syndrome is a behavioral disorder characterized by extreme self-neglect and domestic squalor. Although frontal lobe dysfunction has been postulated to account for squalor syndrome, the relevant part of the frontal lobe has not been elucidated. MethodS: A 49-year-old housewife who suffered rupture of an anterior communicating artery aneurysm at the age of 40 years was examined using a wide range of neuropsychologic tasks. Computed tomography of the head and brain single photon emission tomography with IMP was also carried out. Results: Her performance on neuropsychologic testing was within the normal range, except for the gambling task. Computed tomography of the head showed low-density areas in the bilateral orbitofrontal cortices, basal forebrain, and right ventromedial caudate. Brain single photon emission tomography with IMP showed decreased regional cerebral blood flow in the bilateral orbitofrontal cortices and the basal forebrain. Conclusions: Our findings suggest that an orbitofrontal lesion may be responsible for squalor syndrome by leading to inappropriate decision-making and abnormal impulsivity.

KW - Collecting behavior

KW - Gambling task

KW - Impulse control

KW - Orbitofrontal cortex

KW - Squalor syndrome

UR - http://www.scopus.com/inward/record.url?scp=77953985981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953985981&partnerID=8YFLogxK

U2 - 10.1097/WNN.0b013e3181d746ba

DO - 10.1097/WNN.0b013e3181d746ba

M3 - Article

C2 - 20535064

AN - SCOPUS:77953985981

VL - 23

SP - 135

EP - 139

JO - Cognitive and Behavioral Neurology

JF - Cognitive and Behavioral Neurology

SN - 1543-3633

IS - 2

ER -