Squamous cell carcinoma of the prostate with SMARCA4 alteration in a Japanese patient

Yuta Kaneko, Takeo Kosaka, Kohei Nakamura, Shuji Mikami, Hiroshi Nishihara, Mototsugu Oya

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Squamous cell carcinoma of the prostate is very rare. Due to difficulty in diagnosis, it is often detected in advanced stages. Effective treatment of squamous cell carcinoma and the genetic profiling has not yet been established. Case presentation: We experienced the case of a 79-year-old man who was diagnosed with primary squamous cell carcinoma of the prostate. He had multiple lymph node metastases, liver metastases, and lung metastases, and he was treated with gemcitabine and carboplatin. However, he had poor patient status: it became difficult to continue after one course, and best supportive care was provided. We also performed targeted next-generation sequencing of 160 cancer-related genes and detected SMARCA4 mutation. Conclusion: This is the first study reporting the genomic profiling of squamous cell carcinoma of prostate in Japan.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalIJU Case Reports
Volume5
Issue number5
DOIs
Publication statusPublished - 2022 Sep
Externally publishedYes

Keywords

  • SMARCA4 mutation
  • chemotherapy
  • gene profiling
  • squamous cell carcinoma of the prostate

ASJC Scopus subject areas

  • Urology

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