Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement

Kentaro Matsuoka, Satoshi Hayashi, Fumihiko Urano, Lihua J. Zhu, Hajime Okita, Haruhiko Sago, Atsuko Nakazawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that thoracoamniotic shunting can cause histologic changes in the cyst epithelia. In 5 of 8 patients treated prenatally with thoracoamniotic shunting, squamous metaplasia in the cyst epithelia was seen; whereas squamous metaplasia was not found in 6 patients who were not treated with this procedure. Our results reveal that long-term exposure to the intrauterine environment could possibly lead to the change in the nature of cyst epithelium and consequent squamous metaplasia.

Original languageEnglish
Pages (from-to)1413-1417
Number of pages5
JournalHuman Pathology
Volume43
Issue number9
DOIs
Publication statusPublished - 2012 Sep
Externally publishedYes

Fingerprint

Metaplasia
Cysts
Epithelium
Lung
Hydrops Fetalis
Fetus
Therapeutics

Keywords

  • Congenital pulmonary airway malformation
  • Cyst epithelium
  • Squamous metaplasia
  • Thoracoamniotic shunting

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement. / Matsuoka, Kentaro; Hayashi, Satoshi; Urano, Fumihiko; Zhu, Lihua J.; Okita, Hajime; Sago, Haruhiko; Nakazawa, Atsuko.

In: Human Pathology, Vol. 43, No. 9, 09.2012, p. 1413-1417.

Research output: Contribution to journalArticle

Matsuoka, Kentaro ; Hayashi, Satoshi ; Urano, Fumihiko ; Zhu, Lihua J. ; Okita, Hajime ; Sago, Haruhiko ; Nakazawa, Atsuko. / Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement. In: Human Pathology. 2012 ; Vol. 43, No. 9. pp. 1413-1417.
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