SQUID neuromagnetometric reconstruction of brain activity

Manbir Singh, R. Ricardo Brechner, Koichi Oshio, Richard Leahy, Victor W. Henderson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ionic flow associated with neural activation of the brain produces a magnetic field that can be measured outside the head in a magnetically unshielded room using a highly sensitive neuromagnetometer based on a superconducting quantum interference device (SQUID). Reconstruction of images portraying the tomographic distribution of neural generators (assumed to be current dipoles) of the neuromagnetic field, a modality that we have termed "neuromagnetic imaging" or NMI, represents a powerful noninvasive method of dynamic functional imaging dependent upon brain structure and activity. Reconstruction in NMI, i.e., the inverse problem, however, has no unique solution and requires incorporation of modeling constraints for practical implementation. Results of several phantom and test-object studies and a preliminary human study to develop the method of NMI under various modeling constraints are presented.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Pages417-426
Number of pages10
Volume1351
DOIs
Publication statusPublished - 2010
Externally publishedYes
EventDigital Image Synthesis and Inverse Optics - San Diego, CA, United States
Duration: 1990 Jul 91990 Jul 13

Other

OtherDigital Image Synthesis and Inverse Optics
CountryUnited States
CitySan Diego, CA
Period90/7/990/7/13

Fingerprint

Quantum Interference
SQUIDs
brain
Brain
Imaging
interference
Imaging techniques
Phantom
Inverse problems
Modeling
Unique Solution
Modality
Dipole
rooms
Activation
Inverse Problem
generators
Chemical activation
Magnetic Field
activation

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Singh, M., Brechner, R. R., Oshio, K., Leahy, R., & Henderson, V. W. (2010). SQUID neuromagnetometric reconstruction of brain activity. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1351, pp. 417-426) https://doi.org/10.1117/12.23654

SQUID neuromagnetometric reconstruction of brain activity. / Singh, Manbir; Brechner, R. Ricardo; Oshio, Koichi; Leahy, Richard; Henderson, Victor W.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1351 2010. p. 417-426.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Singh, M, Brechner, RR, Oshio, K, Leahy, R & Henderson, VW 2010, SQUID neuromagnetometric reconstruction of brain activity. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 1351, pp. 417-426, Digital Image Synthesis and Inverse Optics, San Diego, CA, United States, 90/7/9. https://doi.org/10.1117/12.23654
Singh M, Brechner RR, Oshio K, Leahy R, Henderson VW. SQUID neuromagnetometric reconstruction of brain activity. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1351. 2010. p. 417-426 https://doi.org/10.1117/12.23654
Singh, Manbir ; Brechner, R. Ricardo ; Oshio, Koichi ; Leahy, Richard ; Henderson, Victor W. / SQUID neuromagnetometric reconstruction of brain activity. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1351 2010. pp. 417-426
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