Stability of amorphous indomethacin compounded with silica

Tomoyuki Watanabe, Naoki Wakiyama, Fusao Usui, Masaru Ikeda, Tetsuhiko Isobe, Mamoru Senna

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

The stability of indomethacin (IM) compounded with SiO2 either by co-grinding or by melt-quenching was examined by recrystallization kinetics under the conditions 30 °C and 11% relative humidity. A decrease of the recrystallization rate with and without an appreciable induction period was observed in both compounds. Higher stability of amorphous IM compounded with SiO2 was attained by prolonged co-grinding than by melt-quenching. This was explained by the stronger chemical interaction at the interface between IM and SiO2 by co-grinding, as revealed by 29Si and 13C solid state NMR. Incomplete co-grinding with the rest of the crystalline state, however, made the amorphous state appreciably unstable, since the remaining crystallites serve as seeds for recrystallization.

Original languageEnglish
Pages (from-to)81-91
Number of pages11
JournalInternational Journal of Pharmaceutics
Volume226
Issue number1-2
DOIs
Publication statusPublished - 2001 Sep 11

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Indomethacin
Silicon Dioxide
Humidity
Seeds

Keywords

  • Co-ground mixture
  • Crystallization
  • Indomethacin
  • Interaction
  • Solid-state NMR

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Stability of amorphous indomethacin compounded with silica. / Watanabe, Tomoyuki; Wakiyama, Naoki; Usui, Fusao; Ikeda, Masaru; Isobe, Tetsuhiko; Senna, Mamoru.

In: International Journal of Pharmaceutics, Vol. 226, No. 1-2, 11.09.2001, p. 81-91.

Research output: Contribution to journalArticle

Watanabe, Tomoyuki ; Wakiyama, Naoki ; Usui, Fusao ; Ikeda, Masaru ; Isobe, Tetsuhiko ; Senna, Mamoru. / Stability of amorphous indomethacin compounded with silica. In: International Journal of Pharmaceutics. 2001 ; Vol. 226, No. 1-2. pp. 81-91.
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