Stabilizing synthetic data in the DNA of living organisms

Nozomu Yachie, Yoshiaki Ohashi, Masaru Tomita

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Data-encoding synthetic DNA, inserted into the genome of a living organism, is thought to be more robust than the current media. Because the living genome is duplicated and copied into new generations, one of the merits of using DNA material is long-term data storage within heritable media. A disadvantage of this approach is that encoded data can be unexpectedly broken by mutation, deletion, and insertion of DNA, which occurs naturally during evolution and prolongation, or laboratory experiments. For this reason, several information theory-based approaches have been developed as an error check of broken DNA data in order to achieve data durability. These approaches cannot efficiently recover badly damaged data- encoding DNA. We recently developed a DNA data-storage approach based on the multiple sequence alignment method to achieve a high level of data durability. In this paper, we overview this technology and discuss strategies for optimal application of this approach.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalSystems and Synthetic Biology
Volume2
Issue number1-2
DOIs
Publication statusPublished - 2008 Jun 1

Keywords

  • DNa data storage
  • Error check
  • Error correction
  • Genetically modified organism (GMO)
  • Polymerase chain reaction (PCR)
  • Sequence alignment

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Molecular Biology

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