Standard versus long-term prednisolone with Sairei-to for initial therapy in childhood steroid-responsive nephrotic syndrome: A prospective controlled study

Norishige Yoshikawa, Hiroshi Ito, Yasuo Takekoshi, Masataka Honda, Midori Awazu, Kazumoto Iijima, Hajime Nakamura, Yoshiki Seino, Nobuaki Takeda, Shinzaburo Hattori, Ichiro Matsuda

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15 Citations (Scopus)

Abstract

The most appropriate initial treatment for children with steroid- responsive nephrotic syndrome is controversial. Initial treatment with 18- week prednisolone and the Chinese herbal medicine, Sairei-to, may prevent subsequent relapse. To determine whether similar results can be obtained with a combination of just initial 8-week prednisolone and Sairei-to, we compared the effects of such treatment with those of treatment with 18-week prednisolone and Sairei-to in 196 children with steroid-responsive nephrotic syndrome. The patients were randomly assigned to receive 8-week (group 1) or 18-week (group 2) prednisolone for the initial therapy. All patients received Sairei-to for 2 years in addition to prednisolone. Eighty-eight of the 98 patients in group 1 and 83 of the 98 patients in group 2 completed their trial. At entry, the two groups of patients did not differ in their clinical and laboratory findings. During the 2-year trial, 62 group 1 patients (70%) and 54 group 2 patients (65%) had relapses, and 19 group 1 patients (21%) and 20 group 2 patients (24%) had frequent relapses. The present study demonstrates that a combination of initial 8-week prednisolone and 2-year Sairei-to is effective in children with steroid-responsive nephrotic syndrome.

Original languageEnglish
Pages (from-to)587-590
Number of pages4
JournalJapanese Journal of Nephrology
Volume40
Issue number8
Publication statusPublished - 1998

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Keywords

  • Children
  • Chinese herbal medicine
  • Nephrotic syndrome
  • Prednisolone
  • Steroid-responsive

ASJC Scopus subject areas

  • Nephrology

Cite this

Yoshikawa, N., Ito, H., Takekoshi, Y., Honda, M., Awazu, M., Iijima, K., Nakamura, H., Seino, Y., Takeda, N., Hattori, S., & Matsuda, I. (1998). Standard versus long-term prednisolone with Sairei-to for initial therapy in childhood steroid-responsive nephrotic syndrome: A prospective controlled study. Japanese Journal of Nephrology, 40(8), 587-590.