Standard versus long-term prednisolone with Sairei-to for initial therapy in childhood steroid-responsive nephrotic syndrome: A prospective controlled study

Norishige Yoshikawa, Hiroshi Ito, Yasuo Takekoshi, Masataka Honda, Midori Awazu, Kazumoto Iijima, Hajime Nakamura, Yoshiki Seino, Nobuaki Takeda, Shinzaburo Hattori, Ichiro Matsuda

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The most appropriate initial treatment for children with steroid- responsive nephrotic syndrome is controversial. Initial treatment with 18- week prednisolone and the Chinese herbal medicine, Sairei-to, may prevent subsequent relapse. To determine whether similar results can be obtained with a combination of just initial 8-week prednisolone and Sairei-to, we compared the effects of such treatment with those of treatment with 18-week prednisolone and Sairei-to in 196 children with steroid-responsive nephrotic syndrome. The patients were randomly assigned to receive 8-week (group 1) or 18-week (group 2) prednisolone for the initial therapy. All patients received Sairei-to for 2 years in addition to prednisolone. Eighty-eight of the 98 patients in group 1 and 83 of the 98 patients in group 2 completed their trial. At entry, the two groups of patients did not differ in their clinical and laboratory findings. During the 2-year trial, 62 group 1 patients (70%) and 54 group 2 patients (65%) had relapses, and 19 group 1 patients (21%) and 20 group 2 patients (24%) had frequent relapses. The present study demonstrates that a combination of initial 8-week prednisolone and 2-year Sairei-to is effective in children with steroid-responsive nephrotic syndrome.

Original languageEnglish
Pages (from-to)587-590
Number of pages4
JournalJapanese Journal of Nephrology
Volume40
Issue number8
Publication statusPublished - 1998

Fingerprint

Nephrotic Syndrome
Prednisolone
Steroids
Prospective Studies
Therapeutics
Recurrence
sairei-to
Herbal Medicine

Keywords

  • Children
  • Chinese herbal medicine
  • Nephrotic syndrome
  • Prednisolone
  • Steroid-responsive

ASJC Scopus subject areas

  • Nephrology

Cite this

Standard versus long-term prednisolone with Sairei-to for initial therapy in childhood steroid-responsive nephrotic syndrome : A prospective controlled study. / Yoshikawa, Norishige; Ito, Hiroshi; Takekoshi, Yasuo; Honda, Masataka; Awazu, Midori; Iijima, Kazumoto; Nakamura, Hajime; Seino, Yoshiki; Takeda, Nobuaki; Hattori, Shinzaburo; Matsuda, Ichiro.

In: Japanese Journal of Nephrology, Vol. 40, No. 8, 1998, p. 587-590.

Research output: Contribution to journalArticle

Yoshikawa, N, Ito, H, Takekoshi, Y, Honda, M, Awazu, M, Iijima, K, Nakamura, H, Seino, Y, Takeda, N, Hattori, S & Matsuda, I 1998, 'Standard versus long-term prednisolone with Sairei-to for initial therapy in childhood steroid-responsive nephrotic syndrome: A prospective controlled study', Japanese Journal of Nephrology, vol. 40, no. 8, pp. 587-590.
Yoshikawa, Norishige ; Ito, Hiroshi ; Takekoshi, Yasuo ; Honda, Masataka ; Awazu, Midori ; Iijima, Kazumoto ; Nakamura, Hajime ; Seino, Yoshiki ; Takeda, Nobuaki ; Hattori, Shinzaburo ; Matsuda, Ichiro. / Standard versus long-term prednisolone with Sairei-to for initial therapy in childhood steroid-responsive nephrotic syndrome : A prospective controlled study. In: Japanese Journal of Nephrology. 1998 ; Vol. 40, No. 8. pp. 587-590.
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