Standardized uptake values of uterine leiomyoma with 18F-FDG PET/CT: Variation with age, size, degeneration, and contrast enhancement on MRI

Kazuhiro Kitajima, Koji Murakami, Erena Yamasaki, Yasushi Kaji, Kazuro Sugimura

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34 Citations (Scopus)


Objective: To assess the effect of age, size, the degree of degeneration, and contrast enhancement on magnetic resonance imaging (MRI) on 18F-fluoro-2-deoxyglucose (18F-FDG) uptake in uterine leiomyomas using quantitative standardized uptake values (SUVs). Methods: A total of 61 leiomyomas of 41 patients, who underwent combined positron emission tomography/computed tomography (PET/CT) using 18F-FDG and contrast-enhanced MRI were included in this study. Sixty-one leiomyomas were divided into two groups: "non-degenerated" leiomyomas showing distinct low signal intensity on T2-weighted images and intermediate signal intensity on T1-weighted images, and "degenerated" leiomyomas showing other types of signal intensity. Sixty-one leiomyomas were also divided into two groups of "strongly enhancing" leiomyomas and "weakly enhancing" leiomyomas in terms of their degree of contrast enhancement on MRI. Results: The mean values of the maximum and average SUVs for the total of 61 leiomyomas were 2.34 ± 0.75 (range 1.59-5.15) and 1.74 ± 0.50 (0.66-3.95), respectively. There was a moderate negative correlation between the maximum and average SUVs and age (r = -0.43 and P = 0.00016, r = -0.31 and P = 0.029, respectively). Although there was a mild positive correlation between maximum SUV and size (r = 0.35 and P = 0.011), there was no significant difference between average SUV and size. Although there was no significant difference in average SUV between "degenerated" and "non-degenerated" leiomyomas, the maximum SUV of "degenerated" leiomyomas was significantly higher than that of "non-degenerated" leiomyomas (P = 0.0012). The degree of contrast enhancement on MRI was not significantly correlated with 18F-FDG uptake. Conclusions: Mild or moderate uptake of 18F-FDG is often observed in uterine leiomyoma and declines with age, and should not be confused with malignant accumulation.

Original languageEnglish
Pages (from-to)505-512
Number of pages8
JournalAnnals of Nuclear Medicine
Issue number6
Publication statusPublished - 2008 Jul 1



  • F-fluoro-2-deoxyglucose ( F-FDG)
  • Magnetic resonance imaging (MRI)
  • Positron emission tomography/computed tomography (PET/CT)
  • Standardized uptake value (SUV)
  • Uterine leiomyoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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