Standardized uptake values of uterine leiomyoma with 18F-FDG PET/CT: Variation with age, size, degeneration, and contrast enhancement on MRI

Kazuhiro Kitajima, Koji Murakami, Erena Yamasaki, Yasushi Kaji, Kazuro Sugimura

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective: To assess the effect of age, size, the degree of degeneration, and contrast enhancement on magnetic resonance imaging (MRI) on 18F-fluoro-2-deoxyglucose (18F-FDG) uptake in uterine leiomyomas using quantitative standardized uptake values (SUVs). Methods: A total of 61 leiomyomas of 41 patients, who underwent combined positron emission tomography/computed tomography (PET/CT) using 18F-FDG and contrast-enhanced MRI were included in this study. Sixty-one leiomyomas were divided into two groups: "non-degenerated" leiomyomas showing distinct low signal intensity on T2-weighted images and intermediate signal intensity on T1-weighted images, and "degenerated" leiomyomas showing other types of signal intensity. Sixty-one leiomyomas were also divided into two groups of "strongly enhancing" leiomyomas and "weakly enhancing" leiomyomas in terms of their degree of contrast enhancement on MRI. Results: The mean values of the maximum and average SUVs for the total of 61 leiomyomas were 2.34 ± 0.75 (range 1.59-5.15) and 1.74 ± 0.50 (0.66-3.95), respectively. There was a moderate negative correlation between the maximum and average SUVs and age (r = -0.43 and P = 0.00016, r = -0.31 and P = 0.029, respectively). Although there was a mild positive correlation between maximum SUV and size (r = 0.35 and P = 0.011), there was no significant difference between average SUV and size. Although there was no significant difference in average SUV between "degenerated" and "non-degenerated" leiomyomas, the maximum SUV of "degenerated" leiomyomas was significantly higher than that of "non-degenerated" leiomyomas (P = 0.0012). The degree of contrast enhancement on MRI was not significantly correlated with 18F-FDG uptake. Conclusions: Mild or moderate uptake of 18F-FDG is often observed in uterine leiomyoma and declines with age, and should not be confused with malignant accumulation.

Original languageEnglish
Pages (from-to)505-512
Number of pages8
JournalAnnals of Nuclear Medicine
Volume22
Issue number6
DOIs
Publication statusPublished - 2008 Jul
Externally publishedYes

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Deoxyglucose
Leiomyoma
Magnetic Resonance Imaging
Positron Emission Tomography Computed Tomography

Keywords

  • F-fluoro-2-deoxyglucose ( F-FDG)
  • Magnetic resonance imaging (MRI)
  • Positron emission tomography/computed tomography (PET/CT)
  • Standardized uptake value (SUV)
  • Uterine leiomyoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Standardized uptake values of uterine leiomyoma with 18F-FDG PET/CT : Variation with age, size, degeneration, and contrast enhancement on MRI. / Kitajima, Kazuhiro; Murakami, Koji; Yamasaki, Erena; Kaji, Yasushi; Sugimura, Kazuro.

In: Annals of Nuclear Medicine, Vol. 22, No. 6, 07.2008, p. 505-512.

Research output: Contribution to journalArticle

Kitajima, Kazuhiro ; Murakami, Koji ; Yamasaki, Erena ; Kaji, Yasushi ; Sugimura, Kazuro. / Standardized uptake values of uterine leiomyoma with 18F-FDG PET/CT : Variation with age, size, degeneration, and contrast enhancement on MRI. In: Annals of Nuclear Medicine. 2008 ; Vol. 22, No. 6. pp. 505-512.
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abstract = "Objective: To assess the effect of age, size, the degree of degeneration, and contrast enhancement on magnetic resonance imaging (MRI) on 18F-fluoro-2-deoxyglucose (18F-FDG) uptake in uterine leiomyomas using quantitative standardized uptake values (SUVs). Methods: A total of 61 leiomyomas of 41 patients, who underwent combined positron emission tomography/computed tomography (PET/CT) using 18F-FDG and contrast-enhanced MRI were included in this study. Sixty-one leiomyomas were divided into two groups: {"}non-degenerated{"} leiomyomas showing distinct low signal intensity on T2-weighted images and intermediate signal intensity on T1-weighted images, and {"}degenerated{"} leiomyomas showing other types of signal intensity. Sixty-one leiomyomas were also divided into two groups of {"}strongly enhancing{"} leiomyomas and {"}weakly enhancing{"} leiomyomas in terms of their degree of contrast enhancement on MRI. Results: The mean values of the maximum and average SUVs for the total of 61 leiomyomas were 2.34 ± 0.75 (range 1.59-5.15) and 1.74 ± 0.50 (0.66-3.95), respectively. There was a moderate negative correlation between the maximum and average SUVs and age (r = -0.43 and P = 0.00016, r = -0.31 and P = 0.029, respectively). Although there was a mild positive correlation between maximum SUV and size (r = 0.35 and P = 0.011), there was no significant difference between average SUV and size. Although there was no significant difference in average SUV between {"}degenerated{"} and {"}non-degenerated{"} leiomyomas, the maximum SUV of {"}degenerated{"} leiomyomas was significantly higher than that of {"}non-degenerated{"} leiomyomas (P = 0.0012). The degree of contrast enhancement on MRI was not significantly correlated with 18F-FDG uptake. Conclusions: Mild or moderate uptake of 18F-FDG is often observed in uterine leiomyoma and declines with age, and should not be confused with malignant accumulation.",
keywords = "F-fluoro-2-deoxyglucose ( F-FDG), Magnetic resonance imaging (MRI), Positron emission tomography/computed tomography (PET/CT), Standardized uptake value (SUV), Uterine leiomyoma",
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T1 - Standardized uptake values of uterine leiomyoma with 18F-FDG PET/CT

T2 - Variation with age, size, degeneration, and contrast enhancement on MRI

AU - Kitajima, Kazuhiro

AU - Murakami, Koji

AU - Yamasaki, Erena

AU - Kaji, Yasushi

AU - Sugimura, Kazuro

PY - 2008/7

Y1 - 2008/7

N2 - Objective: To assess the effect of age, size, the degree of degeneration, and contrast enhancement on magnetic resonance imaging (MRI) on 18F-fluoro-2-deoxyglucose (18F-FDG) uptake in uterine leiomyomas using quantitative standardized uptake values (SUVs). Methods: A total of 61 leiomyomas of 41 patients, who underwent combined positron emission tomography/computed tomography (PET/CT) using 18F-FDG and contrast-enhanced MRI were included in this study. Sixty-one leiomyomas were divided into two groups: "non-degenerated" leiomyomas showing distinct low signal intensity on T2-weighted images and intermediate signal intensity on T1-weighted images, and "degenerated" leiomyomas showing other types of signal intensity. Sixty-one leiomyomas were also divided into two groups of "strongly enhancing" leiomyomas and "weakly enhancing" leiomyomas in terms of their degree of contrast enhancement on MRI. Results: The mean values of the maximum and average SUVs for the total of 61 leiomyomas were 2.34 ± 0.75 (range 1.59-5.15) and 1.74 ± 0.50 (0.66-3.95), respectively. There was a moderate negative correlation between the maximum and average SUVs and age (r = -0.43 and P = 0.00016, r = -0.31 and P = 0.029, respectively). Although there was a mild positive correlation between maximum SUV and size (r = 0.35 and P = 0.011), there was no significant difference between average SUV and size. Although there was no significant difference in average SUV between "degenerated" and "non-degenerated" leiomyomas, the maximum SUV of "degenerated" leiomyomas was significantly higher than that of "non-degenerated" leiomyomas (P = 0.0012). The degree of contrast enhancement on MRI was not significantly correlated with 18F-FDG uptake. Conclusions: Mild or moderate uptake of 18F-FDG is often observed in uterine leiomyoma and declines with age, and should not be confused with malignant accumulation.

AB - Objective: To assess the effect of age, size, the degree of degeneration, and contrast enhancement on magnetic resonance imaging (MRI) on 18F-fluoro-2-deoxyglucose (18F-FDG) uptake in uterine leiomyomas using quantitative standardized uptake values (SUVs). Methods: A total of 61 leiomyomas of 41 patients, who underwent combined positron emission tomography/computed tomography (PET/CT) using 18F-FDG and contrast-enhanced MRI were included in this study. Sixty-one leiomyomas were divided into two groups: "non-degenerated" leiomyomas showing distinct low signal intensity on T2-weighted images and intermediate signal intensity on T1-weighted images, and "degenerated" leiomyomas showing other types of signal intensity. Sixty-one leiomyomas were also divided into two groups of "strongly enhancing" leiomyomas and "weakly enhancing" leiomyomas in terms of their degree of contrast enhancement on MRI. Results: The mean values of the maximum and average SUVs for the total of 61 leiomyomas were 2.34 ± 0.75 (range 1.59-5.15) and 1.74 ± 0.50 (0.66-3.95), respectively. There was a moderate negative correlation between the maximum and average SUVs and age (r = -0.43 and P = 0.00016, r = -0.31 and P = 0.029, respectively). Although there was a mild positive correlation between maximum SUV and size (r = 0.35 and P = 0.011), there was no significant difference between average SUV and size. Although there was no significant difference in average SUV between "degenerated" and "non-degenerated" leiomyomas, the maximum SUV of "degenerated" leiomyomas was significantly higher than that of "non-degenerated" leiomyomas (P = 0.0012). The degree of contrast enhancement on MRI was not significantly correlated with 18F-FDG uptake. Conclusions: Mild or moderate uptake of 18F-FDG is often observed in uterine leiomyoma and declines with age, and should not be confused with malignant accumulation.

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KW - Positron emission tomography/computed tomography (PET/CT)

KW - Standardized uptake value (SUV)

KW - Uterine leiomyoma

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