STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization

Yuichi Kitai, Masashi Iwakami, Kodai Saitoh, Sumihito Togi, Serina Isayama, Yuichi Sekine, Ryuta Muromoto, Jun Ichi Kashiwakura, Akihiko Yoshimura, Kenji Oritani, Tadashi Matsuda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Signal-transducing adaptor family member-2 (STAP-2) is an adaptor protein that regulates various intracellular signaling pathways and promotes tumorigenesis in melanoma and breast cancer cells. However, the contribution of STAP-2 to the behavior of other types of cancer cells is unclear. Here, we show that STAP-2 promotes tumorigenesis of prostate cancer cells through up-regulation of EGF receptor (EGFR) signaling. Tumor growth of a prostate cancer cell line, DU145, was strongly decreased by STAP-2 knockdown. EGF-induced gene expression and phosphorylation of AKT, ERK, and STAT3 were significantly decreased in STAP-2–knockdown DU145 cells. Mechanistically, we found that STAP-2 interacted with EGFR and enhanced its stability by inhibiting c-CBL–mediated EGFR ubiquitination. Our results indicate that STAP-2 promotes prostate cancer progression via facilitating EGFR activation.

Original languageEnglish
Pages (from-to)19392-19399
Number of pages8
JournalJournal of Biological Chemistry
Volume292
Issue number47
DOIs
Publication statusPublished - 2017 Nov 24

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization'. Together they form a unique fingerprint.

Cite this