Stat5a/b are essential for normal lymphoid development and differentiation

Zhengju Yao, Yongzhi Cui, Wendy T. Watford, Jay H. Bream, Kunihiro Yamaoka, Bruce D. Hissong, Denise Li, Scott K. Durum, Qiong Jiang, Avinash Bhandoola, Lothar Hennighausen, John J. O'Shea

Research output: Contribution to journalArticle

264 Citations (Scopus)

Abstract

Cytokines that use the common gamma chain γc are critical for lymphoid development and function. Mutations of the IL-7 receptor, γc, or its associated kinase, Jak3, are the major cause of human severe combined immunodeficiency. Although activated by IL-7, Stat5a/b (Stat, signal transducer and activator of transcription) have been thought to play limited roles in lymphoid development. However, we now show that mice completely deficient in Stat5a/b have severely impaired lymphoid development and differentiation. Absence of Stat5 also abrogates T cell receptor γ rearrangement and survival of peripheral CD8+ T cells. Thus, deficiency of Stat5 results in severe combined immunodeficiency, similar in many respects to deficiency of IL-7R, γc, and Jak3.

Original languageEnglish
Pages (from-to)1000-1005
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number4
DOIs
Publication statusPublished - 2006 Jan 24

Keywords

  • Cytokine
  • Interleukin
  • Jak
  • Lymphocyte
  • Severe combined immunodeficiency

ASJC Scopus subject areas

  • General

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  • Cite this

    Yao, Z., Cui, Y., Watford, W. T., Bream, J. H., Yamaoka, K., Hissong, B. D., Li, D., Durum, S. K., Jiang, Q., Bhandoola, A., Hennighausen, L., & O'Shea, J. J. (2006). Stat5a/b are essential for normal lymphoid development and differentiation. Proceedings of the National Academy of Sciences of the United States of America, 103(4), 1000-1005. https://doi.org/10.1073/pnas.0507350103