Steady-state B-type natriuretic peptide levels in patients with atrial fibrillation of various clinical backgrounds

Tsuneaki Sadanaga, Hideo Mitamura, Shun Kohsaka, Satoshi Ogawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

B-type natriuretic peptide level is increased in patients with atrial fibrillation. The aim of the present study was to present the distribution of steady-state B-type natriuretic peptide levels of various clinical backgrounds and to elucidate the usefulness of measuring them in patients with atrial fibrillation. B-type natriuretic peptide was measured in stable conditions in patients with atrialfibrillation (74±10 y/o, n = 473). The average B-type natriuretic peptide level was 161±202 (median 101) pg/ml. Multiple regression analysis showed that age, left ventricular ejection fraction, left atrial diameter, structural heart disease, chronic atrial fibrillation, and heart failure symptoms were independently associated with elevated B-type natriuretic peptide levels. However, in chronic atrial fibrillation patients without structural heart disease, B-type natriuretic peptide levels did not differ between those with and without heart failure symptoms. Notably, B-type natriuretic peptide levels were high (≤150 pg/ml) in 41% of asymptomatic chronic atrial fibrillation without structural heart disease. Steady-state B-type natriuretic peptide levels of various clinical backgrounds were presented. Contributions of BNP elevation by clinical variables were somewhat different in different population. B-type natriuretic peptide was elevated in substantial percentage of asymptomatic chronic atrial fibrillation even without structural heart disease.

Original languageEnglish
Pages (from-to)280-286
Number of pages7
JournalHeart and vessels
Volume27
Issue number3
DOIs
Publication statusPublished - 2012 May 1

Keywords

  • Atrial fibrillation
  • B-type natriuretic peptide
  • Heart failure
  • Structural heart disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Steady-state B-type natriuretic peptide levels in patients with atrial fibrillation of various clinical backgrounds'. Together they form a unique fingerprint.

  • Cite this