TY - JOUR
T1 - Steady-state B-type natriuretic peptide levels in patients with atrial fibrillation of various clinical backgrounds
AU - Sadanaga, Tsuneaki
AU - Mitamura, Hideo
AU - Kohsaka, Shun
AU - Ogawa, Satoshi
PY - 2012/5
Y1 - 2012/5
N2 - B-type natriuretic peptide level is increased in patients with atrial fibrillation. The aim of the present study was to present the distribution of steady-state B-type natriuretic peptide levels of various clinical backgrounds and to elucidate the usefulness of measuring them in patients with atrial fibrillation. B-type natriuretic peptide was measured in stable conditions in patients with atrialfibrillation (74±10 y/o, n = 473). The average B-type natriuretic peptide level was 161±202 (median 101) pg/ml. Multiple regression analysis showed that age, left ventricular ejection fraction, left atrial diameter, structural heart disease, chronic atrial fibrillation, and heart failure symptoms were independently associated with elevated B-type natriuretic peptide levels. However, in chronic atrial fibrillation patients without structural heart disease, B-type natriuretic peptide levels did not differ between those with and without heart failure symptoms. Notably, B-type natriuretic peptide levels were high (≤150 pg/ml) in 41% of asymptomatic chronic atrial fibrillation without structural heart disease. Steady-state B-type natriuretic peptide levels of various clinical backgrounds were presented. Contributions of BNP elevation by clinical variables were somewhat different in different population. B-type natriuretic peptide was elevated in substantial percentage of asymptomatic chronic atrial fibrillation even without structural heart disease.
AB - B-type natriuretic peptide level is increased in patients with atrial fibrillation. The aim of the present study was to present the distribution of steady-state B-type natriuretic peptide levels of various clinical backgrounds and to elucidate the usefulness of measuring them in patients with atrial fibrillation. B-type natriuretic peptide was measured in stable conditions in patients with atrialfibrillation (74±10 y/o, n = 473). The average B-type natriuretic peptide level was 161±202 (median 101) pg/ml. Multiple regression analysis showed that age, left ventricular ejection fraction, left atrial diameter, structural heart disease, chronic atrial fibrillation, and heart failure symptoms were independently associated with elevated B-type natriuretic peptide levels. However, in chronic atrial fibrillation patients without structural heart disease, B-type natriuretic peptide levels did not differ between those with and without heart failure symptoms. Notably, B-type natriuretic peptide levels were high (≤150 pg/ml) in 41% of asymptomatic chronic atrial fibrillation without structural heart disease. Steady-state B-type natriuretic peptide levels of various clinical backgrounds were presented. Contributions of BNP elevation by clinical variables were somewhat different in different population. B-type natriuretic peptide was elevated in substantial percentage of asymptomatic chronic atrial fibrillation even without structural heart disease.
KW - Atrial fibrillation
KW - B-type natriuretic peptide
KW - Heart failure
KW - Structural heart disease
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U2 - 10.1007/s00380-011-0151-3
DO - 10.1007/s00380-011-0151-3
M3 - Article
C2 - 21584749
AN - SCOPUS:84862906651
SN - 0910-8327
VL - 27
SP - 280
EP - 286
JO - Heart and Vessels
JF - Heart and Vessels
IS - 3
ER -