Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications

F. J.T. Staal; C. Baum; C. Cowan; E. Dzierzak; S. Hacein-Bey-Abina; S. Karlsson; T. Lapidot; I. Lemischka; S. Mendez-Ferrer; H. Mikkers; K. Moore; E. Moreno; C. L. Mummery; C. Robin; T. Suda; M. Van Pel; G. Vanden Brink; J. J. Zwaginga; W. E. Fibbe

doi:10.1038/leu.2011.52

Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications

F. J.T. Staal, C. Baum, C. Cowan, E. Dzierzak, S. Hacein-Bey-Abina, S. Karlsson, T. Lapidot, I. Lemischka, S. Mendez-Ferrer, H. Mikkers, K. Moore, E. Moreno, C. L. Mummery, C. Robin, T. Suda, M. Van Pel, G. Vanden Brink, J. J. Zwaginga, W. E. Fibbe

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; however, advances in the field of embryonic SCs and induced pluripotent SCs may change this situation. Interest into in vitro generation of HSCs, including signals for HSC expansion and differentiation from these more primitive SCs, as well as advances in other organ-specific SCs, in particular the intestine, provide promising new applications for SC therapies. Here, we review the basic principles of different SC systems, and on the basis of the experience with HSC-based SC therapy, provide recommendations for clinical application of emerging SC technologies.

Original language	English
Pages (from-to)	1095-1102
Number of pages	8
Journal	Leukemia
Volume	25
Issue number	7
DOIs	https://doi.org/10.1038/leu.2011.52
Publication status	Published - 2011 Jul
Externally published	Yes

Keywords

embryonic stem cell
gene therapy
iPS
stem cell
transplantation

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/leu.2011.52

Cite this

Staal, F. J. T., Baum, C., Cowan, C., Dzierzak, E., Hacein-Bey-Abina, S., Karlsson, S., Lapidot, T., Lemischka, I., Mendez-Ferrer, S., Mikkers, H., Moore, K., Moreno, E., Mummery, C. L., Robin, C., Suda, T., Van Pel, M., Vanden Brink, G., Zwaginga, J. J., & Fibbe, W. E. (2011). Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications. Leukemia, 25(7), 1095-1102. https://doi.org/10.1038/leu.2011.52

Staal, FJT, Baum, C, Cowan, C, Dzierzak, E, Hacein-Bey-Abina, S, Karlsson, S, Lapidot, T, Lemischka, I, Mendez-Ferrer, S, Mikkers, H, Moore, K, Moreno, E, Mummery, CL, Robin, C, Suda, T, Van Pel, M, Vanden Brink, G, Zwaginga, JJ & Fibbe, WE 2011, 'Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications', Leukemia, vol. 25, no. 7, pp. 1095-1102. https://doi.org/10.1038/leu.2011.52

@article{3e4d359ce21f477e8941815479bb7e09,

title = "Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications",

abstract = "The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; however, advances in the field of embryonic SCs and induced pluripotent SCs may change this situation. Interest into in vitro generation of HSCs, including signals for HSC expansion and differentiation from these more primitive SCs, as well as advances in other organ-specific SCs, in particular the intestine, provide promising new applications for SC therapies. Here, we review the basic principles of different SC systems, and on the basis of the experience with HSC-based SC therapy, provide recommendations for clinical application of emerging SC technologies.",

keywords = "embryonic stem cell, gene therapy, iPS, stem cell, transplantation",

author = "Staal, {F. J.T.} and C. Baum and C. Cowan and E. Dzierzak and S. Hacein-Bey-Abina and S. Karlsson and T. Lapidot and I. Lemischka and S. Mendez-Ferrer and H. Mikkers and K. Moore and E. Moreno and Mummery, {C. L.} and C. Robin and T. Suda and {Van Pel}, M. and {Vanden Brink}, G. and Zwaginga, {J. J.} and Fibbe, {W. E.}",

year = "2011",

month = jul,

doi = "10.1038/leu.2011.52",

language = "English",

volume = "25",

pages = "1095--1102",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "7",

}

TY - JOUR

T1 - Stem cell self-renewal

T2 - Lessons from bone marrow, gut and iPS toward clinical applications

AU - Staal, F. J.T.

AU - Baum, C.

AU - Cowan, C.

AU - Dzierzak, E.

AU - Hacein-Bey-Abina, S.

AU - Karlsson, S.

AU - Lapidot, T.

AU - Lemischka, I.

AU - Mendez-Ferrer, S.

AU - Mikkers, H.

AU - Moore, K.

AU - Moreno, E.

AU - Mummery, C. L.

AU - Robin, C.

AU - Suda, T.

AU - Van Pel, M.

AU - Vanden Brink, G.

AU - Zwaginga, J. J.

AU - Fibbe, W. E.

PY - 2011/7

Y1 - 2011/7

N2 - The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; however, advances in the field of embryonic SCs and induced pluripotent SCs may change this situation. Interest into in vitro generation of HSCs, including signals for HSC expansion and differentiation from these more primitive SCs, as well as advances in other organ-specific SCs, in particular the intestine, provide promising new applications for SC therapies. Here, we review the basic principles of different SC systems, and on the basis of the experience with HSC-based SC therapy, provide recommendations for clinical application of emerging SC technologies.

AB - The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; however, advances in the field of embryonic SCs and induced pluripotent SCs may change this situation. Interest into in vitro generation of HSCs, including signals for HSC expansion and differentiation from these more primitive SCs, as well as advances in other organ-specific SCs, in particular the intestine, provide promising new applications for SC therapies. Here, we review the basic principles of different SC systems, and on the basis of the experience with HSC-based SC therapy, provide recommendations for clinical application of emerging SC technologies.

KW - embryonic stem cell

KW - gene therapy

KW - iPS

KW - stem cell

KW - transplantation

UR - http://www.scopus.com/inward/record.url?scp=79960204113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960204113&partnerID=8YFLogxK

U2 - 10.1038/leu.2011.52

DO - 10.1038/leu.2011.52

M3 - Review article

C2 - 21527933

AN - SCOPUS:79960204113

SN - 0887-6924

VL - 25

SP - 1095

EP - 1102

JO - Leukemia

JF - Leukemia

IS - 7

ER -

Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this