Stem cell theory for the pathogenesis of endometriosis.

Tetsuo Maruyama, Yasunori Yoshimura

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Proposed hypothetical causes of endometriosis include retrograde menstruation, lymphatic and vascular metastasis, iatrogenic direct implantation, coelomic metaplasia, embryonic rest, and mesenchymal cell differentiation (induction). Each theory, individually, fails to account for all types of endometriotic lesions, thereby implicating combined and/or type-specific mechanisms. Recent evidence supports the presence of endometrial stem/progenitor cells and their possible involvement in eutopic endometrial regeneration and differentiation. Thus an additional novel mechanism for the origin of endometriotic lesions is that they arise from ectopic endometrial stem/progenitor cells.

Original languageEnglish
Pages (from-to)2854-2863
Number of pages10
JournalFrontiers in bioscience (Elite edition)
Volume4
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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