Stem Cells Expressing Matrix Metalloproteinase-13 mRNA Appear during Regression Reversal of Hepatic Cirrhosis

Tetsu Watanabe, Maki Niioka, Shigenari Hozawa, Yoshihiko Sugioka, Masao Arai, Katsuya Maruyama, Hideyuki Okano, Isao Okazaki

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

This chapter describes a mechanism that underlies the degradation of newly formed fibrous bands in CCl4-induced liver fibrosis and cirrhosis and demonstrates that neural progenitor cells derived from hematopoietic stem cells express interstitial collagenase in the recovery phase of experimental cirrhosis. It also discusses the availability of hematopoietic stem cells for the treatment of human liver fibrosis or cirrhosis. The reversibility of liver fibrosis in patients with alcoholic cirrhosis and alcoholic fatty liver with fibrosis has been observed after alcohol abstinence. Histologically documented reversibility of liver fibrosis in alcoholic liver diseases was closely correlated with a decrease in serum fibrosis markers of type IV collagen. It is now generally accepted that reversibility of liver fibrosis or cirrhosis occurs under some conditions if the cause of liver damage is removed or adequately treated.

Original languageEnglish
Title of host publicationExtracellular Matrix and The Liver
Subtitle of host publicationApproach to Gene Therapy
PublisherElsevier Inc.
Pages361-388
Number of pages28
ISBN (Electronic)9780080531502
ISBN (Print)9780125252515
DOIs
Publication statusPublished - 2003 Feb 6

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Watanabe, T., Niioka, M., Hozawa, S., Sugioka, Y., Arai, M., Maruyama, K., Okano, H., & Okazaki, I. (2003). Stem Cells Expressing Matrix Metalloproteinase-13 mRNA Appear during Regression Reversal of Hepatic Cirrhosis. In Extracellular Matrix and The Liver: Approach to Gene Therapy (pp. 361-388). Elsevier Inc.. https://doi.org/10.1016/B978-012525251-5/50021-X