Stem cells for liver repopulation

Alejandro Soto-Gutierrez, Nalu Navarro-Alvarez, Hiroshi Yagi, Martin L. Yarmush

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Purpose of review: The capacity of the liver to regenerate and maintain a constant size despite injury is unique. However, the exact mechanisms are not completely clear. Cell transplantation has been proposed as an alternative treatment of liver diseases. Recent findings:progress has been reported on the generation of stem/progenitor cells that may differentiate toward the hepatic lineage. However, it is currently difficult to determine which of the stem/progenitor cell populations are the best for therapy of a given disease. Recent findings: The limited access to donor human hepatocytes has led to a great interest in the generation of hepatocyte-like cells. Several potential cell sources have been identified. However, general standardization of the methods to evaluate these cells is particularly important for the promise of stem/progenitor-derived hepatocyte-based therapies. Moreover, innovations aimed at improving hepatocyte delivery, survival, and engraftment have recently opened the field of organ engineering that may improve liver repopulation. Summary: Here we review current evidence reported from the perspective of potential clinical applications of different hepatic cell sources with repopulation capacities and the future perspectives and tools that can facilitate the translation of laboratory work into clinical success.

Original languageEnglish
Pages (from-to)667-673
Number of pages7
JournalCurrent Opinion in Organ Transplantation
Volume14
Issue number6
DOIs
Publication statusPublished - 2009 Dec 1

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Keywords

  • Hepatocyte transplantation
  • Liver tissue engineering
  • Stem cell-derived hepatocytes
  • Xenogenic hepatocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

Cite this

Soto-Gutierrez, A., Navarro-Alvarez, N., Yagi, H., & Yarmush, M. L. (2009). Stem cells for liver repopulation. Current Opinion in Organ Transplantation, 14(6), 667-673. https://doi.org/10.1097/MOT.0b013e3283328070