Stepwise Total Aortic Repairs With Fenestrated Endografts in a Patient With Loeys-Dietz Syndrome

Kenichi Hashizume, Hideyuki Shimizu, Masanori Honda, Shinya Inoue, Hidenobu Takaki, Kanako Hayashi, Hiroaki Kaneyama

Research output: Contribution to journalArticle

Abstract

Loeys-Dietz syndrome (LDS) is a rare connective tissue disorder (CTD) caused by mutations in the gene encoding transforming growth factor-β receptors Ⅰ and Ⅱ. Patients with LDS manifest spontaneous aneurysms and dissections of the aorta and peripheral artery. We report a successful treatment with a hybrid endovascular repair for a rapidly expanding thoracoabdominal aneurysm in a 41-year-old woman affected by LDS. To overcome the difficulties of anatomical and surgical repair, we applied an original strategy using surgeon-modified fenestrated endografts.

Original languageEnglish
Pages (from-to)e39-e42
JournalAnnals of Thoracic Surgery
Volume104
Issue number1
DOIs
Publication statusPublished - 2017 Jul 1

Fingerprint

Loeys-Dietz Syndrome
Aneurysm
Growth Factor Receptors
Transforming Growth Factors
Connective Tissue
Aorta
Dissection
Arteries
Mutation
Genes
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Stepwise Total Aortic Repairs With Fenestrated Endografts in a Patient With Loeys-Dietz Syndrome. / Hashizume, Kenichi; Shimizu, Hideyuki; Honda, Masanori; Inoue, Shinya; Takaki, Hidenobu; Hayashi, Kanako; Kaneyama, Hiroaki.

In: Annals of Thoracic Surgery, Vol. 104, No. 1, 01.07.2017, p. e39-e42.

Research output: Contribution to journalArticle

Hashizume, Kenichi ; Shimizu, Hideyuki ; Honda, Masanori ; Inoue, Shinya ; Takaki, Hidenobu ; Hayashi, Kanako ; Kaneyama, Hiroaki. / Stepwise Total Aortic Repairs With Fenestrated Endografts in a Patient With Loeys-Dietz Syndrome. In: Annals of Thoracic Surgery. 2017 ; Vol. 104, No. 1. pp. e39-e42.
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