Chemically synthesized (26)- and (27)-methyl-13C-labeled desmosterol (3, 5) were separately incubated with rat liver homogenate. 13C-NMR analysis of the incubation products indicated that the C-25 hydrogen of cholesterol was introduced from the si-face of 3 and the re-face of 5.
- [2-C][l-(methoxycarbonyl)ethyl]triphenylphosphonium iodide
- sterol-Δ24-reductase cholesterol biosynthesis
ASJC Scopus subject areas
- Drug Discovery