Stereochemistry of Hydrogen Addition to C-25 of Desmosterol by Sterol-Δ24-Reductase of Rat Liver Homogenate

Tomoko Yagi, Noriko Kobayashi, Masuo Morisaki, Noriyuki Hara, Yoshinori Fujimoto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Chemically synthesized (26)- and (27)-methyl-13C-labeled desmosterol (3, 5) were separately incubated with rat liver homogenate. 13C-NMR analysis of the incubation products indicated that the C-25 hydrogen of cholesterol was introduced from the si-face of 3 and the re-face of 5.

Original languageEnglish
Pages (from-to)680-682
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume42
Issue number3
DOIs
Publication statusPublished - 1994 Jan 1

Keywords

  • [2-C][l-(methoxycarbonyl)ethyl]triphenylphosphonium iodide
  • [26-C]desmosterol
  • [27-C]desmosterol
  • sterol-Δ24-reductase cholesterol biosynthesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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