Stereoselective Total Synthesis of KAE609 via Direct Catalytic Asymmetric Alkynylation to Ketimine

Hisashi Takada, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

A direct catalytic asymmetric alkynylation protocol is applied to provide the requisite enantioenriched propargylic α-tertiary amine, allowing for the stereoselective total synthesis of KAE609 (formerly NITD609 or cipargamin).

Original languageEnglish
Pages (from-to)4762-4765
Number of pages4
JournalOrganic Letters
Volume17
Issue number19
DOIs
Publication statusPublished - 2015 Oct 2
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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