Stereoselective Total Synthesis of KAE609 via Direct Catalytic Asymmetric Alkynylation to Ketimine

Hisashi Takada; Naoya Kumagai; Masakatsu Shibasaki

doi:10.1021/acs.orglett.5b02300

Stereoselective Total Synthesis of KAE609 via Direct Catalytic Asymmetric Alkynylation to Ketimine

Hisashi Takada, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

A direct catalytic asymmetric alkynylation protocol is applied to provide the requisite enantioenriched propargylic α-tertiary amine, allowing for the stereoselective total synthesis of KAE609 (formerly NITD609 or cipargamin).

Original language	English
Pages (from-to)	4762-4765
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	19
DOIs	https://doi.org/10.1021/acs.orglett.5b02300
Publication status	Published - 2015 Oct 2
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.5b02300

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title = "Stereoselective Total Synthesis of KAE609 via Direct Catalytic Asymmetric Alkynylation to Ketimine",

abstract = "A direct catalytic asymmetric alkynylation protocol is applied to provide the requisite enantioenriched propargylic α-tertiary amine, allowing for the stereoselective total synthesis of KAE609 (formerly NITD609 or cipargamin).",

author = "Hisashi Takada and Naoya Kumagai and Masakatsu Shibasaki",

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year = "2015",

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doi = "10.1021/acs.orglett.5b02300",

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AU - Takada, Hisashi

AU - Kumagai, Naoya

AU - Shibasaki, Masakatsu

PY - 2015/10/2

Y1 - 2015/10/2

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AB - A direct catalytic asymmetric alkynylation protocol is applied to provide the requisite enantioenriched propargylic α-tertiary amine, allowing for the stereoselective total synthesis of KAE609 (formerly NITD609 or cipargamin).

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Stereoselective Total Synthesis of KAE609 via Direct Catalytic Asymmetric Alkynylation to Ketimine

Abstract

ASJC Scopus subject areas

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