Abstract
A direct catalytic asymmetric alkynylation protocol is applied to provide the requisite enantioenriched propargylic α-tertiary amine, allowing for the stereoselective total synthesis of KAE609 (formerly NITD609 or cipargamin).
Original language | English |
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Pages (from-to) | 4762-4765 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 17 |
Issue number | 19 |
DOIs | |
Publication status | Published - 2015 Oct 2 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry