Stereoselectivity of the biginelli reaction catalyzed by chiral primary amine: A computational study

Chemical Compounds

• Biginelli Synthesis 100%
• Primary Amine 71%
• Stereoselectivity 69%
• Enantioselectivity 64%
• Rate-Determining Step 47%
• Amide 35%
• Stereoisomer 25%
• Diamine 22%
• Proton Transfer 22%
• Catalyst 20%
• Transition State 20%
• Cyclization Reaction 18%
• Catalysis 15%
• Density Functional Theory 15%

Medicine & Life Sciences

• Amides 87%
• Amines 78%
• Density Functional Theory 64%
• Cyclization 55%
• Diamines 52%
• Stereoisomerism 51%
• Protons 37%