Stereotactic body radiotherapy for chronic obstructive pulmonary disease patients undergoing or eligible for long-term domiciliary oxygen therapy

Yu Hara, Atsuya Takeda, Takahisa Eriguchi, Naoko Sanuki, Yousuke Aoki, Shuichi Nishimura, Tatsuji Enomoto, Masaharu Shinkai, Akihiko Kawana, Takeshi Kaneko

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A major cause of death in patients undergoing long-term domiciliary oxygen therapy (LTOT) is lung cancer progression. In our institution, we actively perform stereotactic body radiotherapy (SBRT) on patients with early-stage non-small-cell lung cancer undergoing LTOT. In this study, we retrospectively analyzed the treatment efficacy and safety of SBRT for patients with T1-3N0M0 non-small-cell lung cancer who had been prescribed LTOT for treatment of chronic obstructive pulmonary disease (COPD). A total of 24 patients were studied. Their median age was 74 years (range, 63-87 years). The median duration from the start of LTOT to SBRT was 23 months (range, 0-85 months). Four of the 24 patients underwent lobectomy due to lung cancer. The median follow-up duration was 29 months (range, 5-79 months). One patient had a local recurrence. The median survival time was 30 months. The 3-year overall survival was 49%. In 6 of the 24 patients (25%), COPD presented with interstitial pneumonia. The 3-year overall survival for patients with COPD without interstitial pneumonia was significantly better than that for patients with both COPD and interstitial pneumonia (67% and 0%, respectively; P <0.0001). Grade 5 radiation pneumonitis occurred in one patient (4%) with COPD with interstitial pneumonia. SBRT was tolerated by patients with early-stage non-small-cell lung cancer undergoing LTOT. SBRT should be considered for patients undergoing LTOT. However, clinicians should consider the risk of severe radiation pneumonitis in patients with interstitial pneumonia.

Original languageEnglish
Pages (from-to)62-67
Number of pages6
JournalJournal of Radiation Research
Volume57
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

Fingerprint

Radiosurgery
Chronic Obstructive Pulmonary Disease
radiation therapy
therapy
Oxygen
oxygen
pneumonia
Interstitial Lung Diseases
lungs
interstitials
cancer
Therapeutics
Non-Small Cell Lung Carcinoma
Radiation Pneumonitis
Survival
Lung Neoplasms
radiation
death
progressions
Cause of Death

Keywords

  • Chronic obstructive pulmonary disease
  • Interstitial pneumonia
  • Long-term domiciliary oxygen therapy
  • Lung cancer
  • Radiation pneumonitis
  • Stereotactic body radiotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Health, Toxicology and Mutagenesis

Cite this

Stereotactic body radiotherapy for chronic obstructive pulmonary disease patients undergoing or eligible for long-term domiciliary oxygen therapy. / Hara, Yu; Takeda, Atsuya; Eriguchi, Takahisa; Sanuki, Naoko; Aoki, Yousuke; Nishimura, Shuichi; Enomoto, Tatsuji; Shinkai, Masaharu; Kawana, Akihiko; Kaneko, Takeshi.

In: Journal of Radiation Research, Vol. 57, No. 1, 01.01.2016, p. 62-67.

Research output: Contribution to journalArticle

Hara, Y, Takeda, A, Eriguchi, T, Sanuki, N, Aoki, Y, Nishimura, S, Enomoto, T, Shinkai, M, Kawana, A & Kaneko, T 2016, 'Stereotactic body radiotherapy for chronic obstructive pulmonary disease patients undergoing or eligible for long-term domiciliary oxygen therapy', Journal of Radiation Research, vol. 57, no. 1, pp. 62-67. https://doi.org/10.1093/jrr/rrv064
Hara, Yu ; Takeda, Atsuya ; Eriguchi, Takahisa ; Sanuki, Naoko ; Aoki, Yousuke ; Nishimura, Shuichi ; Enomoto, Tatsuji ; Shinkai, Masaharu ; Kawana, Akihiko ; Kaneko, Takeshi. / Stereotactic body radiotherapy for chronic obstructive pulmonary disease patients undergoing or eligible for long-term domiciliary oxygen therapy. In: Journal of Radiation Research. 2016 ; Vol. 57, No. 1. pp. 62-67.
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abstract = "A major cause of death in patients undergoing long-term domiciliary oxygen therapy (LTOT) is lung cancer progression. In our institution, we actively perform stereotactic body radiotherapy (SBRT) on patients with early-stage non-small-cell lung cancer undergoing LTOT. In this study, we retrospectively analyzed the treatment efficacy and safety of SBRT for patients with T1-3N0M0 non-small-cell lung cancer who had been prescribed LTOT for treatment of chronic obstructive pulmonary disease (COPD). A total of 24 patients were studied. Their median age was 74 years (range, 63-87 years). The median duration from the start of LTOT to SBRT was 23 months (range, 0-85 months). Four of the 24 patients underwent lobectomy due to lung cancer. The median follow-up duration was 29 months (range, 5-79 months). One patient had a local recurrence. The median survival time was 30 months. The 3-year overall survival was 49{\%}. In 6 of the 24 patients (25{\%}), COPD presented with interstitial pneumonia. The 3-year overall survival for patients with COPD without interstitial pneumonia was significantly better than that for patients with both COPD and interstitial pneumonia (67{\%} and 0{\%}, respectively; P <0.0001). Grade 5 radiation pneumonitis occurred in one patient (4{\%}) with COPD with interstitial pneumonia. SBRT was tolerated by patients with early-stage non-small-cell lung cancer undergoing LTOT. SBRT should be considered for patients undergoing LTOT. However, clinicians should consider the risk of severe radiation pneumonitis in patients with interstitial pneumonia.",
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AU - Aoki, Yousuke

AU - Nishimura, Shuichi

AU - Enomoto, Tatsuji

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AU - Kaneko, Takeshi

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