Stereotactic radiosurgery in elderly patients with brain metastases: comparison with non-elderly patients using database of a multi-institutional prospective observational study (JLGK0901-Elderly)

Yoshinori Higuchi, Masaaki Yamamoto, Toru Serizawa, Yasunori Sato, Takashi Shuto, Atsuya Akabane, Hidefumi Jokura, Shoji Yomo, Osamu Nagano, Jun Kawagishi, Kazuhiro Yamanaka, Hidefumi Aoyama

Research output: Contribution to journalArticle

Abstract

Purpose: Stereotactic radiosurgery (SRS) has been increasingly used for elderly patients with brain metastases (BMs). However, no studies based on a large sample size have been reported. To compare SRS treatment results between elderly and non-elderly patients, we performed a subset study of elderly patients using our prospectively-accumulated multi-institution study database (JLGK0901 Study, Lancet Oncol 15:387–395, 2014). Methods: During the 2009–2011 period, 1194 eligible patients undergoing gamma knife SRS alone for newly diagnosed BMs were enrolled in this study from 23 gamma knife facilities in Japan. Observation was discontinued at the end of 2013. The 1194 patients were divided into the two age groups, 693 elderly (≥ 65 years) and 501 non-elderly (< 65 years) patients. Our study protocol neither set an upper age limit nor required dose de-escalation. Results: Median post-SRS survival time was significantly shorter in the elderly than in the non-elderly patient group (10.3 vs 14.3 months, HR 1.380, 95% CI 1.218–1.563, p < 0.0001). However, regarding all secondary endpoints including neurological death, neurological deterioration, SRS-related complications, leukoencephalopathy, local recurrence, newly-developed tumors, meningeal dissemination, salvage SRS, whole brain radiotherapy and surgery and decreased mini-mental state examination scores, the elderly patient group was not inferior to the non-elderly patient group. In the 693 elderly patients, there was no post-SRS median survival time difference between those with 5–10 versus 2–4 tumors (10.8 vs 8.9 months, HR 0.936, 95% CI 0.744–1.167, p = 0.5601). Conclusions: We conclude that elderly BM patients are not unfavorable candidates for SRS alone treatment.

Original languageEnglish
JournalJournal of Neuro-Oncology
DOIs
Publication statusPublished - 2019 Jan 1

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Radiosurgery
Observational Studies
Databases
Prospective Studies
Neoplasm Metastasis
Brain
Meningeal Neoplasms
Leukoencephalopathies
Survival
Sample Size
Japan
Radiotherapy
Age Groups
Observation
Recurrence

Keywords

  • Brain metastases
  • Elderly
  • Gamma knife
  • Radiosurgery

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

Stereotactic radiosurgery in elderly patients with brain metastases : comparison with non-elderly patients using database of a multi-institutional prospective observational study (JLGK0901-Elderly). / Higuchi, Yoshinori; Yamamoto, Masaaki; Serizawa, Toru; Sato, Yasunori; Shuto, Takashi; Akabane, Atsuya; Jokura, Hidefumi; Yomo, Shoji; Nagano, Osamu; Kawagishi, Jun; Yamanaka, Kazuhiro; Aoyama, Hidefumi.

In: Journal of Neuro-Oncology, 01.01.2019.

Research output: Contribution to journalArticle

Higuchi, Yoshinori ; Yamamoto, Masaaki ; Serizawa, Toru ; Sato, Yasunori ; Shuto, Takashi ; Akabane, Atsuya ; Jokura, Hidefumi ; Yomo, Shoji ; Nagano, Osamu ; Kawagishi, Jun ; Yamanaka, Kazuhiro ; Aoyama, Hidefumi. / Stereotactic radiosurgery in elderly patients with brain metastases : comparison with non-elderly patients using database of a multi-institutional prospective observational study (JLGK0901-Elderly). In: Journal of Neuro-Oncology. 2019.
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abstract = "Purpose: Stereotactic radiosurgery (SRS) has been increasingly used for elderly patients with brain metastases (BMs). However, no studies based on a large sample size have been reported. To compare SRS treatment results between elderly and non-elderly patients, we performed a subset study of elderly patients using our prospectively-accumulated multi-institution study database (JLGK0901 Study, Lancet Oncol 15:387–395, 2014). Methods: During the 2009–2011 period, 1194 eligible patients undergoing gamma knife SRS alone for newly diagnosed BMs were enrolled in this study from 23 gamma knife facilities in Japan. Observation was discontinued at the end of 2013. The 1194 patients were divided into the two age groups, 693 elderly (≥ 65 years) and 501 non-elderly (< 65 years) patients. Our study protocol neither set an upper age limit nor required dose de-escalation. Results: Median post-SRS survival time was significantly shorter in the elderly than in the non-elderly patient group (10.3 vs 14.3 months, HR 1.380, 95{\%} CI 1.218–1.563, p < 0.0001). However, regarding all secondary endpoints including neurological death, neurological deterioration, SRS-related complications, leukoencephalopathy, local recurrence, newly-developed tumors, meningeal dissemination, salvage SRS, whole brain radiotherapy and surgery and decreased mini-mental state examination scores, the elderly patient group was not inferior to the non-elderly patient group. In the 693 elderly patients, there was no post-SRS median survival time difference between those with 5–10 versus 2–4 tumors (10.8 vs 8.9 months, HR 0.936, 95{\%} CI 0.744–1.167, p = 0.5601). Conclusions: We conclude that elderly BM patients are not unfavorable candidates for SRS alone treatment.",
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T1 - Stereotactic radiosurgery in elderly patients with brain metastases

T2 - comparison with non-elderly patients using database of a multi-institutional prospective observational study (JLGK0901-Elderly)

AU - Higuchi, Yoshinori

AU - Yamamoto, Masaaki

AU - Serizawa, Toru

AU - Sato, Yasunori

AU - Shuto, Takashi

AU - Akabane, Atsuya

AU - Jokura, Hidefumi

AU - Yomo, Shoji

AU - Nagano, Osamu

AU - Kawagishi, Jun

AU - Yamanaka, Kazuhiro

AU - Aoyama, Hidefumi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: Stereotactic radiosurgery (SRS) has been increasingly used for elderly patients with brain metastases (BMs). However, no studies based on a large sample size have been reported. To compare SRS treatment results between elderly and non-elderly patients, we performed a subset study of elderly patients using our prospectively-accumulated multi-institution study database (JLGK0901 Study, Lancet Oncol 15:387–395, 2014). Methods: During the 2009–2011 period, 1194 eligible patients undergoing gamma knife SRS alone for newly diagnosed BMs were enrolled in this study from 23 gamma knife facilities in Japan. Observation was discontinued at the end of 2013. The 1194 patients were divided into the two age groups, 693 elderly (≥ 65 years) and 501 non-elderly (< 65 years) patients. Our study protocol neither set an upper age limit nor required dose de-escalation. Results: Median post-SRS survival time was significantly shorter in the elderly than in the non-elderly patient group (10.3 vs 14.3 months, HR 1.380, 95% CI 1.218–1.563, p < 0.0001). However, regarding all secondary endpoints including neurological death, neurological deterioration, SRS-related complications, leukoencephalopathy, local recurrence, newly-developed tumors, meningeal dissemination, salvage SRS, whole brain radiotherapy and surgery and decreased mini-mental state examination scores, the elderly patient group was not inferior to the non-elderly patient group. In the 693 elderly patients, there was no post-SRS median survival time difference between those with 5–10 versus 2–4 tumors (10.8 vs 8.9 months, HR 0.936, 95% CI 0.744–1.167, p = 0.5601). Conclusions: We conclude that elderly BM patients are not unfavorable candidates for SRS alone treatment.

AB - Purpose: Stereotactic radiosurgery (SRS) has been increasingly used for elderly patients with brain metastases (BMs). However, no studies based on a large sample size have been reported. To compare SRS treatment results between elderly and non-elderly patients, we performed a subset study of elderly patients using our prospectively-accumulated multi-institution study database (JLGK0901 Study, Lancet Oncol 15:387–395, 2014). Methods: During the 2009–2011 period, 1194 eligible patients undergoing gamma knife SRS alone for newly diagnosed BMs were enrolled in this study from 23 gamma knife facilities in Japan. Observation was discontinued at the end of 2013. The 1194 patients were divided into the two age groups, 693 elderly (≥ 65 years) and 501 non-elderly (< 65 years) patients. Our study protocol neither set an upper age limit nor required dose de-escalation. Results: Median post-SRS survival time was significantly shorter in the elderly than in the non-elderly patient group (10.3 vs 14.3 months, HR 1.380, 95% CI 1.218–1.563, p < 0.0001). However, regarding all secondary endpoints including neurological death, neurological deterioration, SRS-related complications, leukoencephalopathy, local recurrence, newly-developed tumors, meningeal dissemination, salvage SRS, whole brain radiotherapy and surgery and decreased mini-mental state examination scores, the elderly patient group was not inferior to the non-elderly patient group. In the 693 elderly patients, there was no post-SRS median survival time difference between those with 5–10 versus 2–4 tumors (10.8 vs 8.9 months, HR 0.936, 95% CI 0.744–1.167, p = 0.5601). Conclusions: We conclude that elderly BM patients are not unfavorable candidates for SRS alone treatment.

KW - Brain metastases

KW - Elderly

KW - Gamma knife

KW - Radiosurgery

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