Steroid contents and cortical steroidogenic enzymes in non- hyperfunctioning adrenal adenoma

H. Suzuki, H. Shibata, T. Takita, Shu Wakino, T. Ogishima, Y. Ishimura, T. Saruta

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The recent increasing use of ultrasound and computed tomography has revealed numbers of incidentally discovered adrenal tumors. Many studies have focused on their surgical management, but the biological characteristics of these adrenal tumors have remained unclear. Adrenal tumors were resected from 10 patients who underwent gastrectomy or cholecystectomy. No signs or symptoms of adrenal hormone excess or deficiency were evident either before or after the operation. Moreover, after surgery, no major differences in signs and symptoms including blood pressure levels were observed. Before surgery, neurogenic tumors and cysts were excluded by enhanced magnetic resonance imaging. Steroid contents and both the activities and amounts of steroidogenic cytochrome P-450s in the adrenocortical adenomas of these patients were examined. Microscopic examination revealed that the tumors were surrounded by a thin, non-intact capsule; the surrounding cortex was not atrophic and apparently normal; and the cells of both the tumor and adjacent portions were arranged in nests and cords. Measurements of all steroid content (pregnenolone, progesterone, corticosterone, 11-deoxycorticosterone, 18-hydroxydeoxycorticosterone, cortisol, and dehydroepiandrosterone) except aldosterone in 5 resected adrenal tumors were within the normal ranges for the adrenals of 5 patients with renal cell carcinoma. Aldosterone content in tumor portions was significantly lower than in the apparently normal adrenals. Although in both tumor and adjacent portions of another 5 resected adrenal tumors the activities and amounts of cytochrome P-450s (P-450(scc), P-450(11β), P-450(aldo), P-450(17α), and P-450(c21) were also within the normal ranges, the activities of P-450(scc) and P-450(17α) in the tumor portion were greater than those in the adjacent portion. Grossly well- demarcated yellowish-brown tumors of the adrenal gland were observed in all the cases of adrenal tumor. The above results suggested that adrenal incidentalomas produce adrenal steroids through steroidogenic enzymes in both the tumor and adjacent portions. In addition, decreases in aldosterone content and increases in the activities of P-450(17α) in tumor portions suggest the shift of steroidogenesis from a mineralocorticoid pathway to a glucocorticoid pathway.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalEndocrine Journal
Volume41
Issue number3
Publication statusPublished - 1994
Externally publishedYes

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Adenoma
Glandular and Epithelial Neoplasms
Steroids
Enzymes
Neoplasms
Aldosterone
Cytochromes
Signs and Symptoms
Reference Values
Adrenocortical Adenoma
Pregnenolone
Desoxycorticosterone
Mineralocorticoids
Dehydroepiandrosterone
Cholecystectomy
Gastrectomy
Adrenal Glands
Corticosterone
Renal Cell Carcinoma
Glucocorticoids

ASJC Scopus subject areas

  • Endocrinology

Cite this

Suzuki, H., Shibata, H., Takita, T., Wakino, S., Ogishima, T., Ishimura, Y., & Saruta, T. (1994). Steroid contents and cortical steroidogenic enzymes in non- hyperfunctioning adrenal adenoma. Endocrine Journal, 41(3), 267-274.

Steroid contents and cortical steroidogenic enzymes in non- hyperfunctioning adrenal adenoma. / Suzuki, H.; Shibata, H.; Takita, T.; Wakino, Shu; Ogishima, T.; Ishimura, Y.; Saruta, T.

In: Endocrine Journal, Vol. 41, No. 3, 1994, p. 267-274.

Research output: Contribution to journalArticle

Suzuki, H, Shibata, H, Takita, T, Wakino, S, Ogishima, T, Ishimura, Y & Saruta, T 1994, 'Steroid contents and cortical steroidogenic enzymes in non- hyperfunctioning adrenal adenoma', Endocrine Journal, vol. 41, no. 3, pp. 267-274.
Suzuki H, Shibata H, Takita T, Wakino S, Ogishima T, Ishimura Y et al. Steroid contents and cortical steroidogenic enzymes in non- hyperfunctioning adrenal adenoma. Endocrine Journal. 1994;41(3):267-274.
Suzuki, H. ; Shibata, H. ; Takita, T. ; Wakino, Shu ; Ogishima, T. ; Ishimura, Y. ; Saruta, T. / Steroid contents and cortical steroidogenic enzymes in non- hyperfunctioning adrenal adenoma. In: Endocrine Journal. 1994 ; Vol. 41, No. 3. pp. 267-274.
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