Steroid receptor expression in thymomas and thymic carcinomas

Takahiro Mimae, Koji Tsuta, Fumiaki Takahashi, Akihiko Yoshida, Tadashi Kondo, Yoshinori Murakami, Morihito Okada, Masahiro Takeuchi, Hisao Asamura, Hitoshi Tsuda

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

BACKGROUND: Although protein expressions of glucocorticoid receptor (GR), estrogen receptors (ERα and ERβ), progesterone receptor A (PgR-A), and androgen receptor (AR) were shown to play roles in the growth and differentiation of normal thymus and thymic tumors, to the authors' knowledge their association with patient characteristics and prognosis has yet to be determined. METHODS: A series of 140 thymic epithelial tumors (57 type A + AB thymomas, 40 type B1 + B2 thymomas, 6 type B3 thymomas, and 37 thymic carcinomas) were examined for GR, ERα, ERβ, PgR-A, and AR expression using immunohistochemistry. In addition, the correlation between expression of these hormone receptors and clinicopathologic factors and overall survival (OS) was assessed. RESULTS: GR and ERβ demonstrated a high rate of expression in thymomas and thymic carcinomas (82.9% and 76.4%, respectively), whereas rates of ERα, PgR-A, and AR expression were low (13.6%, 0.71%, and 23.6%, respectively). A significant correlation (P <.05) was found between ERα expression and tumor size and between ERβ expression and tumor stage. Multivariate analyses revealed that histologic subtype (P =.0039), tumor stage (P =.0012), and GR expression (P =.0025) were significantly correlated with the 10-year OS rate. CONCLUSIONS: GR and ERβ demonstrated high rates of expression in thymomas and thymic carcinomas. Furthermore, multivariate analysis revealed that GR expression was associated with better prognosis in patients with surgically resected thymomas and thymic carcinomas.

Original languageEnglish
Pages (from-to)4396-4405
Number of pages10
JournalCancer
Volume117
Issue number19
DOIs
Publication statusPublished - 2011 Oct 1
Externally publishedYes

Fingerprint

Thymoma
Steroid Receptors
Glucocorticoid Receptors
Androgen Receptors
Thymus Neoplasms
Multivariate Analysis
Neoplasms
Estrogen Receptors
Survival Rate
Immunohistochemistry
Hormones

Keywords

  • estrogen receptor
  • glucocorticoid receptor
  • progesterone receptor
  • thymic carcinoma
  • thymoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mimae, T., Tsuta, K., Takahashi, F., Yoshida, A., Kondo, T., Murakami, Y., ... Tsuda, H. (2011). Steroid receptor expression in thymomas and thymic carcinomas. Cancer, 117(19), 4396-4405. https://doi.org/10.1002/cncr.26061

Steroid receptor expression in thymomas and thymic carcinomas. / Mimae, Takahiro; Tsuta, Koji; Takahashi, Fumiaki; Yoshida, Akihiko; Kondo, Tadashi; Murakami, Yoshinori; Okada, Morihito; Takeuchi, Masahiro; Asamura, Hisao; Tsuda, Hitoshi.

In: Cancer, Vol. 117, No. 19, 01.10.2011, p. 4396-4405.

Research output: Contribution to journalArticle

Mimae, T, Tsuta, K, Takahashi, F, Yoshida, A, Kondo, T, Murakami, Y, Okada, M, Takeuchi, M, Asamura, H & Tsuda, H 2011, 'Steroid receptor expression in thymomas and thymic carcinomas', Cancer, vol. 117, no. 19, pp. 4396-4405. https://doi.org/10.1002/cncr.26061
Mimae T, Tsuta K, Takahashi F, Yoshida A, Kondo T, Murakami Y et al. Steroid receptor expression in thymomas and thymic carcinomas. Cancer. 2011 Oct 1;117(19):4396-4405. https://doi.org/10.1002/cncr.26061
Mimae, Takahiro ; Tsuta, Koji ; Takahashi, Fumiaki ; Yoshida, Akihiko ; Kondo, Tadashi ; Murakami, Yoshinori ; Okada, Morihito ; Takeuchi, Masahiro ; Asamura, Hisao ; Tsuda, Hitoshi. / Steroid receptor expression in thymomas and thymic carcinomas. In: Cancer. 2011 ; Vol. 117, No. 19. pp. 4396-4405.
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abstract = "BACKGROUND: Although protein expressions of glucocorticoid receptor (GR), estrogen receptors (ERα and ERβ), progesterone receptor A (PgR-A), and androgen receptor (AR) were shown to play roles in the growth and differentiation of normal thymus and thymic tumors, to the authors' knowledge their association with patient characteristics and prognosis has yet to be determined. METHODS: A series of 140 thymic epithelial tumors (57 type A + AB thymomas, 40 type B1 + B2 thymomas, 6 type B3 thymomas, and 37 thymic carcinomas) were examined for GR, ERα, ERβ, PgR-A, and AR expression using immunohistochemistry. In addition, the correlation between expression of these hormone receptors and clinicopathologic factors and overall survival (OS) was assessed. RESULTS: GR and ERβ demonstrated a high rate of expression in thymomas and thymic carcinomas (82.9{\%} and 76.4{\%}, respectively), whereas rates of ERα, PgR-A, and AR expression were low (13.6{\%}, 0.71{\%}, and 23.6{\%}, respectively). A significant correlation (P <.05) was found between ERα expression and tumor size and between ERβ expression and tumor stage. Multivariate analyses revealed that histologic subtype (P =.0039), tumor stage (P =.0012), and GR expression (P =.0025) were significantly correlated with the 10-year OS rate. CONCLUSIONS: GR and ERβ demonstrated high rates of expression in thymomas and thymic carcinomas. Furthermore, multivariate analysis revealed that GR expression was associated with better prognosis in patients with surgically resected thymomas and thymic carcinomas.",
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AU - Murakami, Yoshinori

AU - Okada, Morihito

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