Abstract
D-aspartate and human chorionic gonadotropin act synergistically to increase testosterone production in purified rat Leydig cells, and D-aspartate stimulates testosterone synthesis even in the absence of human chorionic gonadotropin stimulation. In addition, D-aspartate enhances steady-state cellular mRNA and protein levels of steroidogenic acute regulatory protein, which is a key regulatory factor in gonadal and adrenal steroidogenesis. D-aspartate therefore appears to increase testosterone production in rat Leydig cells by stimulating steroidogenic acute regulatory protein gene expression. To our knowledge, this is the first report demonstrating a direct effect of D-aspartate on gene expression in mammalian cells. Copyright (C) 1999 Federation of European Biochemical Societies.
| Original language | English |
|---|---|
| Pages (from-to) | 317-320 |
| Number of pages | 4 |
| Journal | FEBS Letters |
| Volume | 454 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1999 Jul 9 |
| Externally published | Yes |
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Keywords
- D-aspartate
- Leydig cell
- StAR
- Steroidogenic acute regulatory protein
- Testosterone
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells. / Itoh, Yoshiko; Homma, Hiroshi; Matsumoto, Megumi; Imai, Kazuhiro.
In: FEBS Letters, Vol. 454, No. 3, 09.07.1999, p. 317-320.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells
AU - Itoh, Yoshiko
AU - Homma, Hiroshi
AU - Matsumoto, Megumi
AU - Imai, Kazuhiro
PY - 1999/7/9
Y1 - 1999/7/9
N2 - D-aspartate and human chorionic gonadotropin act synergistically to increase testosterone production in purified rat Leydig cells, and D-aspartate stimulates testosterone synthesis even in the absence of human chorionic gonadotropin stimulation. In addition, D-aspartate enhances steady-state cellular mRNA and protein levels of steroidogenic acute regulatory protein, which is a key regulatory factor in gonadal and adrenal steroidogenesis. D-aspartate therefore appears to increase testosterone production in rat Leydig cells by stimulating steroidogenic acute regulatory protein gene expression. To our knowledge, this is the first report demonstrating a direct effect of D-aspartate on gene expression in mammalian cells. Copyright (C) 1999 Federation of European Biochemical Societies.
AB - D-aspartate and human chorionic gonadotropin act synergistically to increase testosterone production in purified rat Leydig cells, and D-aspartate stimulates testosterone synthesis even in the absence of human chorionic gonadotropin stimulation. In addition, D-aspartate enhances steady-state cellular mRNA and protein levels of steroidogenic acute regulatory protein, which is a key regulatory factor in gonadal and adrenal steroidogenesis. D-aspartate therefore appears to increase testosterone production in rat Leydig cells by stimulating steroidogenic acute regulatory protein gene expression. To our knowledge, this is the first report demonstrating a direct effect of D-aspartate on gene expression in mammalian cells. Copyright (C) 1999 Federation of European Biochemical Societies.
KW - D-aspartate
KW - Leydig cell
KW - StAR
KW - Steroidogenic acute regulatory protein
KW - Testosterone
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UR - http://www.scopus.com/inward/citedby.url?scp=0032974135&partnerID=8YFLogxK
U2 - 10.1016/S0014-5793(99)00840-6
DO - 10.1016/S0014-5793(99)00840-6
M3 - Article
C2 - 10431830
AN - SCOPUS:0032974135
VL - 454
SP - 317
EP - 320
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 3
ER -