Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells

Yoshiko Nagata; Hiroshi Homma; Megumi Matsumoto; Kazuhiro Imai

doi:10.1016/S0014-5793(99)00840-6

Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells

Yoshiko Nagata, Hiroshi Homma, Megumi Matsumoto, Kazuhiro Imai

Research output: Contribution to journal › Article

78 Citations (Scopus)

Abstract

D-aspartate and human chorionic gonadotropin act synergistically to increase testosterone production in purified rat Leydig cells, and D-aspartate stimulates testosterone synthesis even in the absence of human chorionic gonadotropin stimulation. In addition, D-aspartate enhances steady-state cellular mRNA and protein levels of steroidogenic acute regulatory protein, which is a key regulatory factor in gonadal and adrenal steroidogenesis. D-aspartate therefore appears to increase testosterone production in rat Leydig cells by stimulating steroidogenic acute regulatory protein gene expression. To our knowledge, this is the first report demonstrating a direct effect of D-aspartate on gene expression in mammalian cells. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	317-320
Number of pages	4
Journal	FEBS Letters
Volume	454
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(99)00840-6
Publication status	Published - 1999 Jul 9
Externally published	Yes

Keywords

D-aspartate
Leydig cell
StAR
Steroidogenic acute regulatory protein
Testosterone

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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Nagata, Y., Homma, H., Matsumoto, M., & Imai, K. (1999). Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells. FEBS Letters, 454(3), 317-320. https://doi.org/10.1016/S0014-5793(99)00840-6

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