Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells

Yoshiko Itoh, Hiroshi Homma, Megumi Matsumoto, Kazuhiro Imai

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

D-aspartate and human chorionic gonadotropin act synergistically to increase testosterone production in purified rat Leydig cells, and D-aspartate stimulates testosterone synthesis even in the absence of human chorionic gonadotropin stimulation. In addition, D-aspartate enhances steady-state cellular mRNA and protein levels of steroidogenic acute regulatory protein, which is a key regulatory factor in gonadal and adrenal steroidogenesis. D-aspartate therefore appears to increase testosterone production in rat Leydig cells by stimulating steroidogenic acute regulatory protein gene expression. To our knowledge, this is the first report demonstrating a direct effect of D-aspartate on gene expression in mammalian cells. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalFEBS Letters
Volume454
Issue number3
DOIs
Publication statusPublished - 1999 Jul 9
Externally publishedYes

Fingerprint

D-Aspartic Acid
Leydig Cells
Regulator Genes
Gene expression
Rats
Gene Expression
Testosterone
Chorionic Gonadotropin
Cells
steroidogenic acute regulatory protein
Messenger RNA
Proteins

Keywords

  • D-aspartate
  • Leydig cell
  • StAR
  • Steroidogenic acute regulatory protein
  • Testosterone

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells. / Itoh, Yoshiko; Homma, Hiroshi; Matsumoto, Megumi; Imai, Kazuhiro.

In: FEBS Letters, Vol. 454, No. 3, 09.07.1999, p. 317-320.

Research output: Contribution to journalArticle

Itoh, Yoshiko ; Homma, Hiroshi ; Matsumoto, Megumi ; Imai, Kazuhiro. / Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells. In: FEBS Letters. 1999 ; Vol. 454, No. 3. pp. 317-320.
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