Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells

Yoshiko Nagata, Hiroshi Homma, Megumi Matsumoto, Kazuhiro Imai

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

D-aspartate and human chorionic gonadotropin act synergistically to increase testosterone production in purified rat Leydig cells, and D-aspartate stimulates testosterone synthesis even in the absence of human chorionic gonadotropin stimulation. In addition, D-aspartate enhances steady-state cellular mRNA and protein levels of steroidogenic acute regulatory protein, which is a key regulatory factor in gonadal and adrenal steroidogenesis. D-aspartate therefore appears to increase testosterone production in rat Leydig cells by stimulating steroidogenic acute regulatory protein gene expression. To our knowledge, this is the first report demonstrating a direct effect of D-aspartate on gene expression in mammalian cells. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalFEBS Letters
Volume454
Issue number3
DOIs
Publication statusPublished - 1999 Jul 9
Externally publishedYes

Keywords

  • D-aspartate
  • Leydig cell
  • StAR
  • Steroidogenic acute regulatory protein
  • Testosterone

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells'. Together they form a unique fingerprint.

  • Cite this