Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells

Yoshiko Nagata; Hiroshi Homma; Megumi Matsumoto; Kazuhiro Imai

doi:10.1016/S0014-5793(99)00840-6

Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells

Yoshiko Nagata, Hiroshi Homma, Megumi Matsumoto, Kazuhiro Imai

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

D-aspartate and human chorionic gonadotropin act synergistically to increase testosterone production in purified rat Leydig cells, and D-aspartate stimulates testosterone synthesis even in the absence of human chorionic gonadotropin stimulation. In addition, D-aspartate enhances steady-state cellular mRNA and protein levels of steroidogenic acute regulatory protein, which is a key regulatory factor in gonadal and adrenal steroidogenesis. D-aspartate therefore appears to increase testosterone production in rat Leydig cells by stimulating steroidogenic acute regulatory protein gene expression. To our knowledge, this is the first report demonstrating a direct effect of D-aspartate on gene expression in mammalian cells. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	317-320
Number of pages	4
Journal	FEBS Letters
Volume	454
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(99)00840-6
Publication status	Published - 1999 Jul 9
Externally published	Yes

Keywords

D-aspartate
Leydig cell
StAR
Steroidogenic acute regulatory protein
Testosterone

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/S0014-5793(99)00840-6

Fingerprint Dive into the research topics of 'Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells'. Together they form a unique fingerprint.

Cite this

@article{0aa2d4bbfe4f4cceb3d4e45e659129e7,

title = "Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells",

abstract = "D-aspartate and human chorionic gonadotropin act synergistically to increase testosterone production in purified rat Leydig cells, and D-aspartate stimulates testosterone synthesis even in the absence of human chorionic gonadotropin stimulation. In addition, D-aspartate enhances steady-state cellular mRNA and protein levels of steroidogenic acute regulatory protein, which is a key regulatory factor in gonadal and adrenal steroidogenesis. D-aspartate therefore appears to increase testosterone production in rat Leydig cells by stimulating steroidogenic acute regulatory protein gene expression. To our knowledge, this is the first report demonstrating a direct effect of D-aspartate on gene expression in mammalian cells. Copyright (C) 1999 Federation of European Biochemical Societies.",

keywords = "D-aspartate, Leydig cell, StAR, Steroidogenic acute regulatory protein, Testosterone",

author = "Yoshiko Nagata and Hiroshi Homma and Megumi Matsumoto and Kazuhiro Imai",

year = "1999",

month = jul,

day = "9",

doi = "10.1016/S0014-5793(99)00840-6",

language = "English",

volume = "454",

pages = "317--320",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells

AU - Nagata, Yoshiko

AU - Homma, Hiroshi

AU - Matsumoto, Megumi

AU - Imai, Kazuhiro

PY - 1999/7/9

Y1 - 1999/7/9

N2 - D-aspartate and human chorionic gonadotropin act synergistically to increase testosterone production in purified rat Leydig cells, and D-aspartate stimulates testosterone synthesis even in the absence of human chorionic gonadotropin stimulation. In addition, D-aspartate enhances steady-state cellular mRNA and protein levels of steroidogenic acute regulatory protein, which is a key regulatory factor in gonadal and adrenal steroidogenesis. D-aspartate therefore appears to increase testosterone production in rat Leydig cells by stimulating steroidogenic acute regulatory protein gene expression. To our knowledge, this is the first report demonstrating a direct effect of D-aspartate on gene expression in mammalian cells. Copyright (C) 1999 Federation of European Biochemical Societies.

AB - D-aspartate and human chorionic gonadotropin act synergistically to increase testosterone production in purified rat Leydig cells, and D-aspartate stimulates testosterone synthesis even in the absence of human chorionic gonadotropin stimulation. In addition, D-aspartate enhances steady-state cellular mRNA and protein levels of steroidogenic acute regulatory protein, which is a key regulatory factor in gonadal and adrenal steroidogenesis. D-aspartate therefore appears to increase testosterone production in rat Leydig cells by stimulating steroidogenic acute regulatory protein gene expression. To our knowledge, this is the first report demonstrating a direct effect of D-aspartate on gene expression in mammalian cells. Copyright (C) 1999 Federation of European Biochemical Societies.

KW - D-aspartate

KW - Leydig cell

KW - StAR

KW - Steroidogenic acute regulatory protein

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=0032974135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032974135&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(99)00840-6

DO - 10.1016/S0014-5793(99)00840-6

M3 - Article

C2 - 10431830

AN - SCOPUS:0032974135

VL - 454

SP - 317

EP - 320

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 3

ER -