Strain differences in rat liver UDP-glucuronyltransferase activity towards androsterone

M. Matsui, F. Nagai, S. Aoyagi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Male Donryu, Wistar and Wistar King rats showed discontinuous variations in hepatic microsomal UDP-glucuronyltransferase activities towards androsterone, but not towards testosterone, bilirubin, phenolphthalein and 4-nitrophenol. Fresh microsomal fraction with a low transferase activity towards androsterone formed 0.049-0.080 nmol of glucuronide/min per mg of protein, whereas fresh microsomal fraction with a high transferase activity towards androsterone formed 0.335-0.557 nmol of glucuronide/min per mg of protein. The microsomal fraction with low enzyme activity towards androsterone was not stimulated by treatment with Triton X-100 or freezing and thawing. In contrast, male Long Evans and Sprague-Dawley rats did not exhibit such diversity.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalBiochemical Journal
Volume179
Issue number3
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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